ACE2 shedding exacerbates sepsis-induced gut leak via loss of microbial metabolite 5-methoxytryptophan.
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| Title: | ACE2 shedding exacerbates sepsis-induced gut leak via loss of microbial metabolite 5-methoxytryptophan. |
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| Authors: | Gong J; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Lu H; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Li Y; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China., Xu Q; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Ma Y; State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Lou A; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Cui W; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Song W; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Qu P; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Chen Z; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Quan L; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Liu X; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510515, China. haojin_cq@163.com., Meng Y; Department of Respiratory Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. nfyymengy@163.com., Li X; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. mylx99@smu.edu.cn.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. mylx99@smu.edu.cn. |
| Source: | Microbiome [Microbiome] 2025 May 29; Vol. 13 (1), pp. 136. Date of Electronic Publication: 2025 May 29. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101615147 Publication Model: Electronic Cited Medium: Internet ISSN: 2049-2618 (Electronic) Linking ISSN: 20492618 NLM ISO Abbreviation: Microbiome Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2049-2618 |
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| DOI: | 10.1186/s40168-025-02128-4 |
