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ACE2 shedding exacerbates sepsis-induced gut leak via loss of microbial metabolite 5-methoxytryptophan.

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Title: ACE2 shedding exacerbates sepsis-induced gut leak via loss of microbial metabolite 5-methoxytryptophan.
Authors: Gong J; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Lu H; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Li Y; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China., Xu Q; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Ma Y; State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Lou A; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Cui W; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Song W; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Qu P; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Chen Z; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Quan L; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Liu X; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510515, China. haojin_cq@163.com., Meng Y; Department of Respiratory Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. nfyymengy@163.com., Li X; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. mylx99@smu.edu.cn.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. mylx99@smu.edu.cn.
Source: Microbiome [Microbiome] 2025 May 29; Vol. 13 (1), pp. 136. Date of Electronic Publication: 2025 May 29.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101615147 Publication Model: Electronic Cited Medium: Internet ISSN: 2049-2618 (Electronic) Linking ISSN: 20492618 NLM ISO Abbreviation: Microbiome Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ACE2 shedding exacerbates sepsis-induced gut leak via loss of microbial metabolite 5-methoxytryptophan.
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  Data: <searchLink fieldCode="AU" term="%22Gong+J%22">Gong J</searchLink>; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Lu+H%22">Lu H</searchLink>; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Xu+Q%22">Xu Q</searchLink>; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Lou+A%22">Lou A</searchLink>; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Cui+W%22">Cui W</searchLink>; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Song+W%22">Song W</searchLink>; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Qu+P%22">Qu P</searchLink>; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Quan+L%22">Quan L</searchLink>; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510515, China. haojin_cq@163.com.<br /><searchLink fieldCode="AU" term="%22Meng+Y%22">Meng Y</searchLink>; Department of Respiratory Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. nfyymengy@163.com.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Emergency Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. mylx99@smu.edu.cn.; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. mylx99@smu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101615147%22">Microbiome</searchLink> [Microbiome] 2025 May 29; Vol. 13 (1), pp. 136. <i>Date of Electronic Publication: </i>2025 May 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101615147 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2049-2618 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220492618%22">20492618 </searchLink><i>NLM ISO Abbreviation: </i>Microbiome <i>Subsets: </i>MEDLINE
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