Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life.
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| Title: | Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life. |
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| Authors: | Latina V; Institute of Translational Pharmacology (IFT)-National Research Council (CNR), Via Fosso del Cavaliere 100, 00133, Rome, Italy.; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy., De Introna M; Centro Di Ricerca Europeo Sul Cervello (CERC), IRCCS Santa Lucia Foundation (FSL), Via Fosso del Fiorano 43-44, 00143, Rome, Italy.; Department of Systems Medicine, University of Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy., Malerba F; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy.; Institute of Nanotechnology Campus Ecotekne- National Research Council (CNR), Via Monteroni, 73100, Lecce, Italy., Florio R; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy., Balzamino BO; Research and Development Laboratory for Biochemical, Molecular and Cellular Applications in Ophthalmological Science, IRCCS-Fondazione Bietti, Via Santo Stefano Rotondo, 6, 00184, Rome, Italy., Di Natale G; Institute of Crystallography (IC)-National Research Council (CNR), Via Paolo Gaifami 18, 95126, Catania, Italy., Sciacca MFM; Institute of Crystallography (IC)-National Research Council (CNR), Via Paolo Gaifami 18, 95126, Catania, Italy., Pappalardo G; Institute of Crystallography (IC)-National Research Council (CNR), Via Paolo Gaifami 18, 95126, Catania, Italy., Micera A; Research and Development Laboratory for Biochemical, Molecular and Cellular Applications in Ophthalmological Science, IRCCS-Fondazione Bietti, Via Santo Stefano Rotondo, 6, 00184, Rome, Italy., Pignataro A; Institute of Translational Pharmacology (IFT)-National Research Council (CNR), Via Fosso del Cavaliere 100, 00133, Rome, Italy.; Centro Di Ricerca Europeo Sul Cervello (CERC), IRCCS Santa Lucia Foundation (FSL), Via Fosso del Fiorano 43-44, 00143, Rome, Italy., Calissano P; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy., Amadoro G; Institute of Translational Pharmacology (IFT)-National Research Council (CNR), Via Fosso del Cavaliere 100, 00133, Rome, Italy. g.amadoro@inmm.cnr.it.; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy. g.amadoro@inmm.cnr.it. |
| Source: | Acta neuropathologica communications [Acta Neuropathol Commun] 2025 May 29; Vol. 13 (1), pp. 121. Date of Electronic Publication: 2025 May 29. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2051-5960 |
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| DOI: | 10.1186/s40478-025-02022-y |
