Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life.
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| Title: | Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life. |
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| Authors: | Latina V; Institute of Translational Pharmacology (IFT)-National Research Council (CNR), Via Fosso del Cavaliere 100, 00133, Rome, Italy.; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy., De Introna M; Centro Di Ricerca Europeo Sul Cervello (CERC), IRCCS Santa Lucia Foundation (FSL), Via Fosso del Fiorano 43-44, 00143, Rome, Italy.; Department of Systems Medicine, University of Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy., Malerba F; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy.; Institute of Nanotechnology Campus Ecotekne- National Research Council (CNR), Via Monteroni, 73100, Lecce, Italy., Florio R; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy., Balzamino BO; Research and Development Laboratory for Biochemical, Molecular and Cellular Applications in Ophthalmological Science, IRCCS-Fondazione Bietti, Via Santo Stefano Rotondo, 6, 00184, Rome, Italy., Di Natale G; Institute of Crystallography (IC)-National Research Council (CNR), Via Paolo Gaifami 18, 95126, Catania, Italy., Sciacca MFM; Institute of Crystallography (IC)-National Research Council (CNR), Via Paolo Gaifami 18, 95126, Catania, Italy., Pappalardo G; Institute of Crystallography (IC)-National Research Council (CNR), Via Paolo Gaifami 18, 95126, Catania, Italy., Micera A; Research and Development Laboratory for Biochemical, Molecular and Cellular Applications in Ophthalmological Science, IRCCS-Fondazione Bietti, Via Santo Stefano Rotondo, 6, 00184, Rome, Italy., Pignataro A; Institute of Translational Pharmacology (IFT)-National Research Council (CNR), Via Fosso del Cavaliere 100, 00133, Rome, Italy.; Centro Di Ricerca Europeo Sul Cervello (CERC), IRCCS Santa Lucia Foundation (FSL), Via Fosso del Fiorano 43-44, 00143, Rome, Italy., Calissano P; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy., Amadoro G; Institute of Translational Pharmacology (IFT)-National Research Council (CNR), Via Fosso del Cavaliere 100, 00133, Rome, Italy. g.amadoro@inmm.cnr.it.; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy. g.amadoro@inmm.cnr.it. |
| Source: | Acta neuropathologica communications [Acta Neuropathol Commun] 2025 May 29; Vol. 13 (1), pp. 121. Date of Electronic Publication: 2025 May 29. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40442822 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Latina+V%22">Latina V</searchLink>; Institute of Translational Pharmacology (IFT)-National Research Council (CNR), Via Fosso del Cavaliere 100, 00133, Rome, Italy.; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22De+Introna+M%22">De Introna M</searchLink>; Centro Di Ricerca Europeo Sul Cervello (CERC), IRCCS Santa Lucia Foundation (FSL), Via Fosso del Fiorano 43-44, 00143, Rome, Italy.; Department of Systems Medicine, University of Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Malerba+F%22">Malerba F</searchLink>; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy.; Institute of Nanotechnology Campus Ecotekne- National Research Council (CNR), Via Monteroni, 73100, Lecce, Italy.<br /><searchLink fieldCode="AU" term="%22Florio+R%22">Florio R</searchLink>; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Balzamino+BO%22">Balzamino BO</searchLink>; Research and Development Laboratory for Biochemical, Molecular and Cellular Applications in Ophthalmological Science, IRCCS-Fondazione Bietti, Via Santo Stefano Rotondo, 6, 00184, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Natale+G%22">Di Natale G</searchLink>; Institute of Crystallography (IC)-National Research Council (CNR), Via Paolo Gaifami 18, 95126, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Sciacca+MFM%22">Sciacca MFM</searchLink>; Institute of Crystallography (IC)-National Research Council (CNR), Via Paolo Gaifami 18, 95126, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Pappalardo+G%22">Pappalardo G</searchLink>; Institute of Crystallography (IC)-National Research Council (CNR), Via Paolo Gaifami 18, 95126, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Micera+A%22">Micera A</searchLink>; Research and Development Laboratory for Biochemical, Molecular and Cellular Applications in Ophthalmological Science, IRCCS-Fondazione Bietti, Via Santo Stefano Rotondo, 6, 00184, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pignataro+A%22">Pignataro A</searchLink>; Institute of Translational Pharmacology (IFT)-National Research Council (CNR), Via Fosso del Cavaliere 100, 00133, Rome, Italy.; Centro Di Ricerca Europeo Sul Cervello (CERC), IRCCS Santa Lucia Foundation (FSL), Via Fosso del Fiorano 43-44, 00143, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Calissano+P%22">Calissano P</searchLink>; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Amadoro+G%22">Amadoro G</searchLink>; Institute of Translational Pharmacology (IFT)-National Research Council (CNR), Via Fosso del Cavaliere 100, 00133, Rome, Italy. g.amadoro@inmm.cnr.it.; European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161, Rome, Italy. g.amadoro@inmm.cnr.it. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101610673%22">Acta neuropathologica communications</searchLink> [Acta Neuropathol Commun] 2025 May 29; Vol. 13 (1), pp. 121. <i>Date of Electronic Publication: </i>2025 May 29. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101610673 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-5960 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220515960%22">20515960 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol Commun <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40442822 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s40478-025-02022-y Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 121 Titles: – TitleFull: Acute targeting of N-terminal tau protein has long-lasting beneficial effects in Tg2576 APP/Aβ mouse model by reducing cognitive impairment, cerebral Aβ-amyloidosis, synaptic remodeling and microgliosis later in life. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Latina V – PersonEntity: Name: NameFull: De Introna M – PersonEntity: Name: NameFull: Malerba F – PersonEntity: Name: NameFull: Florio R – PersonEntity: Name: NameFull: Balzamino BO – PersonEntity: Name: NameFull: Di Natale G – PersonEntity: Name: NameFull: Sciacca MFM – PersonEntity: Name: NameFull: Pappalardo G – PersonEntity: Name: NameFull: Micera A – PersonEntity: Name: NameFull: Pignataro A – PersonEntity: Name: NameFull: Calissano P – PersonEntity: Name: NameFull: Amadoro G IsPartOfRelationships: – BibEntity: Dates: – D: 29 M: 05 Text: 2025 May 29 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 2051-5960 Numbering: – Type: volume Value: 13 – Type: issue Value: 1 Titles: – TitleFull: Acta neuropathologica communications Type: main |
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