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Moderation of treatment outcomes by polygenic risk for alcohol-related traits in placebo-controlled trials of topiramate.

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Title: Moderation of treatment outcomes by polygenic risk for alcohol-related traits in placebo-controlled trials of topiramate.
Authors: Kranzler HR; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, Pennsylvania, USA., Jinwala Z; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, Pennsylvania, USA., Davis CN; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, Pennsylvania, USA., Xu H; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Biernacka JM; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA., Zhou H; Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, Connecticut, USA., Kember RL; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, Pennsylvania, USA., Gelernter J; Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, Connecticut, USA., Feinn R; Department of Medical Sciences, Frank H. Netter School of Medicine at Quinnipiac University, North Haven, Connecticut, USA.
Source: Alcohol, clinical & experimental research [Alcohol Clin Exp Res (Hoboken)] 2025 Jun; Vol. 49 (6), pp. 1297-1305. Date of Electronic Publication: 2025 May 30.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Wiley Periodicals Country of Publication: United States NLM ID: 9918609780906676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2993-7175 (Electronic) Linking ISSN: 29937175 NLM ISO Abbreviation: Alcohol Clin Exp Res (Hoboken) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Moderation of treatment outcomes by polygenic risk for alcohol-related traits in placebo-controlled trials of topiramate.
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  Data: <searchLink fieldCode="AU" term="%22Kranzler+HR%22">Kranzler HR</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Jinwala+Z%22">Jinwala Z</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Davis+CN%22">Davis CN</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Biernacka+JM%22">Biernacka JM</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+H%22">Zhou H</searchLink>; Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Kember+RL%22">Kember RL</searchLink>; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.; Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Gelernter+J%22">Gelernter J</searchLink>; Department of Psychiatry, Yale University School of Medicine and VA CT Healthcare Center, West Haven, Connecticut, USA.<br /><searchLink fieldCode="AU" term="%22Feinn+R%22">Feinn R</searchLink>; Department of Medical Sciences, Frank H. Netter School of Medicine at Quinnipiac University, North Haven, Connecticut, USA.
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  Data: <searchLink fieldCode="JN" term="%229918609780906676%22">Alcohol, clinical & experimental research</searchLink> [Alcohol Clin Exp Res (Hoboken)] 2025 Jun; Vol. 49 (6), pp. 1297-1305. <i>Date of Electronic Publication: </i>2025 May 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley+Periodicals%22">Wiley Periodicals </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9918609780906676 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2993-7175 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2229937175%22">29937175 </searchLink><i>NLM ISO Abbreviation: </i>Alcohol Clin Exp Res (Hoboken) <i>Subsets: </i>MEDLINE
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        Value: 10.1111/acer.70052
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        Text: English
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              Text: 2025 Jun
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