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Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications.

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Title: Unravelling the transcriptome of the human tuberculosis lesion and its clinical implications.
Authors: Fonseca KL; Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Badalona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain., Lozano JJ; Bioinformatic Platform, Centro de Investigación Biomédica en Red de Enfermedades Hepática y Digestivas (CIBERehd), Barcelona, Spain.; Hospital Clínic de Barcelona, Barcelona, Spain., Despuig A; Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Badalona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain., Habgood-Coote D; Department of Infectious Diseases, Imperial College London, London, UK., Sidorova J; Bioinformatic Platform, Centro de Investigación Biomédica en Red de Enfermedades Hepática y Digestivas (CIBERehd), Barcelona, Spain.; Hospital Clínic de Barcelona, Barcelona, Spain., Aznar D; Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Badalona, Spain.; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain., Arias L; Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Badalona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain., Del Río-Álvarez Á; Childhood Liver Oncology Group, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Translational Program in Cancer Research (CARE), Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBER), Madrid, Spain., Carrillo-Reixach J; Childhood Liver Oncology Group, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Translational Program in Cancer Research (CARE), Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBER), Madrid, Spain., Goff A; Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, UK., Wildner LM; Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, UK., Gogishvili S; National Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia., Nikolaishvili K; National Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia., Shubladze N; National Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia., Avaliani Z; National Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia.; European University, Tbilisi, Georgia., Tapia G; Pathology Department, Hospital Germans Trias i Pujol, Badalona, Spain.; Universitat Autònoma de Barcelona, Barcelona, Spain., Rodríguez-Martínez P; Pathology Department, Hospital Germans Trias i Pujol, Badalona, Spain.; Universitat Autònoma de Barcelona, Barcelona, Spain., Cardona PJ; Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Badalona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; Microbiology Department, Northern Metropolitan Clinical Laboratory, Hospital Universitari Germans Trias i Pujol, Badalona, Spain., Martinón-Torres F; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.; Genetics, Vaccines and Pediatric Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.; Universidad de Santiago de Compostela (USC), Santiago de Compostela, Spain.; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago de Compostela (SERGAS), Santiago de Compostela, Spain., Salas A; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago de Compostela (SERGAS), Santiago de Compostela, Spain.; Unidade de Xenética, Instituto de Ciencias Forenses (INCIFOR), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; GenPoB Research Group, Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain., Gómez-Carballa A; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago de Compostela (SERGAS), Santiago de Compostela, Spain.; Unidade de Xenética, Instituto de Ciencias Forenses (INCIFOR), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; GenPoB Research Group, Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain., Armengol C; Childhood Liver Oncology Group, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Translational Program in Cancer Research (CARE), Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBER), Madrid, Spain., Waddell SJ; Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, UK., Kaforou M; Department of Infectious Diseases, Imperial College London, London, UK.; Centre for Paediatrics and Child Health, Imperial College London, London, UK., O'Garra A; Immunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK.; National Heart and Lung Institute, Imperial College, London, UK., Vashakidze S; National Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia.; The University of Georgia, Tbilisi, Georgia., Vilaplana C; Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Badalona, Spain. cvilaplana@igtp.cat.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain. cvilaplana@igtp.cat.; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. cvilaplana@igtp.cat.; Microbiology Department, Northern Metropolitan Clinical Laboratory, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. cvilaplana@igtp.cat.
Source: Nature communications [Nat Commun] 2025 May 30; Vol. 16 (1), pp. 5028. Date of Electronic Publication: 2025 May 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Fonseca+KL%22">Fonseca KL</searchLink>; Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Badalona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lozano+JJ%22">Lozano JJ</searchLink>; Bioinformatic Platform, Centro de Investigación Biomédica en Red de Enfermedades Hepática y Digestivas (CIBERehd), Barcelona, Spain.; Hospital Clínic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Despuig+A%22">Despuig A</searchLink>; Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Badalona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Habgood-Coote+D%22">Habgood-Coote D</searchLink>; Department of Infectious Diseases, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sidorova+J%22">Sidorova J</searchLink>; Bioinformatic Platform, Centro de Investigación Biomédica en Red de Enfermedades Hepática y Digestivas (CIBERehd), Barcelona, Spain.; Hospital Clínic de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Aznar+D%22">Aznar D</searchLink>; Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Badalona, Spain.; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.<br /><searchLink fieldCode="AU" term="%22Arias+L%22">Arias L</searchLink>; Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Badalona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Del+Río-Álvarez+Á%22">Del Río-Álvarez Á</searchLink>; Childhood Liver Oncology Group, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Translational Program in Cancer Research (CARE), Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBER), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Carrillo-Reixach+J%22">Carrillo-Reixach J</searchLink>; Childhood Liver Oncology Group, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Translational Program in Cancer Research (CARE), Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBER), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Goff+A%22">Goff A</searchLink>; Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, UK.<br /><searchLink fieldCode="AU" term="%22Wildner+LM%22">Wildner LM</searchLink>; Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, UK.<br /><searchLink fieldCode="AU" term="%22Gogishvili+S%22">Gogishvili S</searchLink>; National Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia.<br /><searchLink fieldCode="AU" term="%22Nikolaishvili+K%22">Nikolaishvili K</searchLink>; National Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia.<br /><searchLink fieldCode="AU" term="%22Shubladze+N%22">Shubladze N</searchLink>; National Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia.<br /><searchLink fieldCode="AU" term="%22Avaliani+Z%22">Avaliani Z</searchLink>; National Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia.; European University, Tbilisi, Georgia.<br /><searchLink fieldCode="AU" term="%22Tapia+G%22">Tapia G</searchLink>; Pathology Department, Hospital Germans Trias i Pujol, Badalona, Spain.; Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Martínez+P%22">Rodríguez-Martínez P</searchLink>; Pathology Department, Hospital Germans Trias i Pujol, Badalona, Spain.; Universitat Autònoma de Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Cardona+PJ%22">Cardona PJ</searchLink>; Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Badalona, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.; Microbiology Department, Northern Metropolitan Clinical Laboratory, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Martinón-Torres+F%22">Martinón-Torres F</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.; Genetics, Vaccines and Pediatric Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.; Universidad de Santiago de Compostela (USC), Santiago de Compostela, Spain.; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago de Compostela (SERGAS), Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Salas+A%22">Salas A</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago de Compostela (SERGAS), Santiago de Compostela, Spain.; Unidade de Xenética, Instituto de Ciencias Forenses (INCIFOR), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; GenPoB Research Group, Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Gómez-Carballa+A%22">Gómez-Carballa A</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago de Compostela (SERGAS), Santiago de Compostela, Spain.; Unidade de Xenética, Instituto de Ciencias Forenses (INCIFOR), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; GenPoB Research Group, Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Armengol+C%22">Armengol C</searchLink>; Childhood Liver Oncology Group, Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Translational Program in Cancer Research (CARE), Germans Trias i Pujol Research Institute (IGTP), Badalona, Spain.; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBER), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Waddell+SJ%22">Waddell SJ</searchLink>; Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, UK.<br /><searchLink fieldCode="AU" term="%22Kaforou+M%22">Kaforou M</searchLink>; Department of Infectious Diseases, Imperial College London, London, UK.; Centre for Paediatrics and Child Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22O'Garra+A%22">O'Garra A</searchLink>; Immunoregulation and Infection Laboratory, The Francis Crick Institute, London, UK.; National Heart and Lung Institute, Imperial College, London, UK.<br /><searchLink fieldCode="AU" term="%22Vashakidze+S%22">Vashakidze S</searchLink>; National Center for Tuberculosis and Lung Diseases (NCTLD), Tbilisi, Georgia.; The University of Georgia, Tbilisi, Georgia.<br /><searchLink fieldCode="AU" term="%22Vilaplana+C%22">Vilaplana C</searchLink>; Experimental Tuberculosis Unit (UTE), Fundació Institut Germans Trias i Pujol (IGTP), Badalona, Spain. cvilaplana@igtp.cat.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain. cvilaplana@igtp.cat.; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain. cvilaplana@igtp.cat.; Microbiology Department, Northern Metropolitan Clinical Laboratory, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. cvilaplana@igtp.cat.
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