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Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base.

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Title: Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base.
Authors: De Cae S; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Van Molle I; VIB-VUB Center for Structural Biology Research, VIB, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium., van Schie L; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Shoemaker SR; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Deckers J; Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium., Debeuf N; Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium., Lameire S; Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium., Nerinckx W; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Roose K; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Fijalkowska D; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Devos S; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., De Smet AS; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Marchan JCZ; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Venneman T; ExeVir Bio BV, Gent, Belgium., Sedeyn K; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Mujanovic L; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Ballegeer M; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Vanheerswynghels M; Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium., De Wolf C; Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium., Demol H; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Zuallaert J; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Vanhaverbeke P; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Ghassabeh GH; VIB Nanobody Core, Vrije Universiteit Brussel, Brussels, Belgium., Lonigro C; ExeVir Bio BV, Gent, Belgium., Bockstal V; ExeVir Bio BV, Gent, Belgium., Rinaldi M; ExeVir Bio BV, Gent, Belgium., Abdelnabi R; Virology, Antiviral Drug & Vaccine Reasearch Group, Department of Microbiology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.; VirusBank Platform, Virology, Antiviral Drug & Vaccine Research Group; Departmnet of Microbiology and Transplantation, Rega Intitute for Medical Research, KU Leuven, Leuven, Belgium., Neyts J; Virology, Antiviral Drug & Vaccine Reasearch Group, Department of Microbiology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.; VirusBank Platform, Virology, Antiviral Drug & Vaccine Research Group; Departmnet of Microbiology and Transplantation, Rega Intitute for Medical Research, KU Leuven, Leuven, Belgium.; GVN, Global Virus Network, Baltimore, MD, USA.; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium., Marqusee S; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, CA, USA., Lambrecht BN; Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.; Department of Pulmonary Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands., Callewaert N; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Remaut H; VIB-VUB Center for Structural Biology Research, VIB, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium., Saelens X; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium. xavier.saelens@vib-ugent.be.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. xavier.saelens@vib-ugent.be., Schepens B; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium. bert.schepens@vib-ugent.be.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium. bert.schepens@vib-ugent.be.
Source: Nature communications [Nat Commun] 2025 May 30; Vol. 16 (1), pp. 5040. Date of Electronic Publication: 2025 May 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22De+Cae+S%22">De Cae S</searchLink>; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Molle+I%22">Van Molle I</searchLink>; VIB-VUB Center for Structural Biology Research, VIB, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22van+Schie+L%22">van Schie L</searchLink>; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Shoemaker+SR%22">Shoemaker SR</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Deckers+J%22">Deckers J</searchLink>; Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.; 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VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Devos+S%22">Devos S</searchLink>; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Smet+AS%22">De Smet AS</searchLink>; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Marchan+JCZ%22">Marchan JCZ</searchLink>; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Venneman+T%22">Venneman T</searchLink>; ExeVir Bio BV, Gent, Belgium.<br /><searchLink fieldCode="AU" term="%22Sedeyn+K%22">Sedeyn K</searchLink>; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Mujanovic+L%22">Mujanovic L</searchLink>; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Ballegeer+M%22">Ballegeer M</searchLink>; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Vanheerswynghels+M%22">Vanheerswynghels M</searchLink>; Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Wolf+C%22">De Wolf C</searchLink>; Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.; 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KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Virology and Chemotherapy, Molecular Vaccinology and Vaccine Discovery Group, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Marqusee+S%22">Marqusee S</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lambrecht+BN%22">Lambrecht BN</searchLink>; Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.; Department of Pulmonary Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Callewaert+N%22">Callewaert N</searchLink>; VIB Center for Medical Biotechnology, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.<br /><searchLink fieldCode="AU" term="%22Remaut+H%22">Remaut H</searchLink>; 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