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IL-36 signaling as a drug target in Crohn's disease patients with IL36RN mutations.

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Title: IL-36 signaling as a drug target in Crohn's disease patients with IL36RN mutations.
Authors: Hecker J; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany., Plattner C; Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria., Cancino CA; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany.; Deutsches Rheuma-Forschungszentrum, ein Institut der Leibniz-Gemeinschaft, Berlin, Germany., Löscher BS; Institute of Clinical Molecular Biology, Kiel University and University Medical Center, Kiel, Germany., Saurenbach J; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany., Letizia M; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany., Rieder D; Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria., Freise I; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany., Koop K; Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Neufert C; Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Kunkel D; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Flow & Mass Cytometry Core Facility, Berlin, Germany., Al Khatim Z; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany., Schaafs LA; Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Schütz A; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Becker C; Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Atreya R; Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Trajanoski Z; Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria., Franke A; Institute of Clinical Molecular Biology, Kiel University and University Medical Center, Kiel, Germany., Sonnenberg E; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany., Hegazy AN; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany.; Deutsches Rheuma-Forschungszentrum, ein Institut der Leibniz-Gemeinschaft, Berlin, Germany., Siegmund B; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany. britta.siegmund@charite.de., Weidinger C; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany. carl.weidinger@charite.de.
Corporate Authors: TRR241 IBDome Consortium
Source: EMBO molecular medicine [EMBO Mol Med] 2025 Jul; Vol. 17 (7), pp. 1539-1555. Date of Electronic Publication: 2025 May 30.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: IL-36 signaling as a drug target in Crohn's disease patients with IL36RN mutations.
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  Data: <searchLink fieldCode="AU" term="%22Hecker+J%22">Hecker J</searchLink>; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Plattner+C%22">Plattner C</searchLink>; Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Cancino+CA%22">Cancino CA</searchLink>; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany.; Deutsches Rheuma-Forschungszentrum, ein Institut der Leibniz-Gemeinschaft, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Löscher+BS%22">Löscher BS</searchLink>; Institute of Clinical Molecular Biology, Kiel University and University Medical Center, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Saurenbach+J%22">Saurenbach J</searchLink>; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Letizia+M%22">Letizia M</searchLink>; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Rieder+D%22">Rieder D</searchLink>; Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Freise+I%22">Freise I</searchLink>; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Koop+K%22">Koop K</searchLink>; Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Neufert+C%22">Neufert C</searchLink>; Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Kunkel+D%22">Kunkel D</searchLink>; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Flow & Mass Cytometry Core Facility, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Al+Khatim+Z%22">Al Khatim Z</searchLink>; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schaafs+LA%22">Schaafs LA</searchLink>; Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Schütz+A%22">Schütz A</searchLink>; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Becker+C%22">Becker C</searchLink>; Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Atreya+R%22">Atreya R</searchLink>; Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Trajanoski+Z%22">Trajanoski Z</searchLink>; Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Franke+A%22">Franke A</searchLink>; Institute of Clinical Molecular Biology, Kiel University and University Medical Center, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Sonnenberg+E%22">Sonnenberg E</searchLink>; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hegazy+AN%22">Hegazy AN</searchLink>; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany.; Deutsches Rheuma-Forschungszentrum, ein Institut der Leibniz-Gemeinschaft, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Siegmund+B%22">Siegmund B</searchLink>; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany. britta.siegmund@charite.de.<br /><searchLink fieldCode="AU" term="%22Weidinger+C%22">Weidinger C</searchLink>; Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany. carl.weidinger@charite.de.
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