Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinoma.

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Title: Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinoma.
Authors: Shi R; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada., Farnsworth DA; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada., Febres-Aldana CA; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chow JLM; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada., Sheena R; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada., Atwal T; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada., Gomez Marti JL; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Li S; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada., Thomas KN; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada., Lee CM; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada., Awrey SJ; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada., McDonald PC; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada., Somwar R; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Dedhar S; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada., Ladanyi M; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Bennewith KL; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada., Lockwood WW; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada. wlockwood@bccrc.ca.; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada. wlockwood@bccrc.ca.
Source: Oncogene [Oncogene] 2025 Aug; Vol. 44 (32), pp. 2831-2849. Date of Electronic Publication: 2025 May 31.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5594 (Electronic) Linking ISSN: 09509232 NLM ISO Abbreviation: Oncogene Subsets: MEDLINE
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  Data: Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Shi+R%22">Shi R</searchLink>; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Farnsworth+DA%22">Farnsworth DA</searchLink>; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Febres-Aldana+CA%22">Febres-Aldana CA</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chow+JLM%22">Chow JLM</searchLink>; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Sheena+R%22">Sheena R</searchLink>; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Atwal+T%22">Atwal T</searchLink>; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Gomez+Marti+JL%22">Gomez Marti JL</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Thomas+KN%22">Thomas KN</searchLink>; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Lee+CM%22">Lee CM</searchLink>; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Awrey+SJ%22">Awrey SJ</searchLink>; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22McDonald+PC%22">McDonald PC</searchLink>; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Somwar+R%22">Somwar R</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dedhar+S%22">Dedhar S</searchLink>; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Ladanyi+M%22">Ladanyi M</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bennewith+KL%22">Bennewith KL</searchLink>; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada.; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.<br /><searchLink fieldCode="AU" term="%22Lockwood+WW%22">Lockwood WW</searchLink>; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC, Canada. wlockwood@bccrc.ca.; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada. wlockwood@bccrc.ca.
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  Data: <searchLink fieldCode="JN" term="%228711562%22">Oncogene</searchLink> [Oncogene] 2025 Aug; Vol. 44 (32), pp. 2831-2849. <i>Date of Electronic Publication: </i>2025 May 31.
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      – TitleFull: Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinoma.
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