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Development of a succinyl CoA:3-ketoacid CoA transferase inhibitor selective for peripheral tissues that improves glycemia in obesity.

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Title: Development of a succinyl CoA:3-ketoacid CoA transferase inhibitor selective for peripheral tissues that improves glycemia in obesity.
Authors: Tabatabaei Dakhili SA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Yang K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Al Nebaihi H; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada., Greenwell AA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Wuest M; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada., Woodfield J; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada., Farraj RA; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Saed CT; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Chan JSF; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Bhat RK; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Mangra-Bala IA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Shafaati T; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Gopal K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Eaton F; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Ferrari SR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Wagg CS; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada., Capozzi ME; Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA., Campbell JE; Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA., Overduin M; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Velazquez-Martinez CA; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada., Glover JNM; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada., Wuest F; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada., Brocks DR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada., Ussher JR; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Source: IScience [iScience] 2025 Apr 03; Vol. 28 (5), pp. 112336. Date of Electronic Publication: 2025 Apr 03 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada.<br /><searchLink fieldCode="AU" term="%22Woodfield+J%22">Woodfield J</searchLink>; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada.<br /><searchLink fieldCode="AU" term="%22Farraj+RA%22">Farraj RA</searchLink>; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.<br /><searchLink fieldCode="AU" term="%22Saed+CT%22">Saed CT</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada.<br /><searchLink fieldCode="AU" term="%22Chan+JSF%22">Chan JSF</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; 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Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada.<br /><searchLink fieldCode="AU" term="%22Ferrari+SR%22">Ferrari SR</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada.<br /><searchLink fieldCode="AU" term="%22Wagg+CS%22">Wagg CS</searchLink>; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada.<br /><searchLink fieldCode="AU" term="%22Capozzi+ME%22">Capozzi ME</searchLink>; Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.<br /><searchLink fieldCode="AU" term="%22Campbell+JE%22">Campbell JE</searchLink>; Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA.<br /><searchLink fieldCode="AU" term="%22Overduin+M%22">Overduin M</searchLink>; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.<br /><searchLink fieldCode="AU" term="%22Velazquez-Martinez+CA%22">Velazquez-Martinez CA</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.<br /><searchLink fieldCode="AU" term="%22Glover+JNM%22">Glover JNM</searchLink>; Department of Biochemistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.<br /><searchLink fieldCode="AU" term="%22Wuest+F%22">Wuest F</searchLink>; Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada.; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada.<br /><searchLink fieldCode="AU" term="%22Brocks+DR%22">Brocks DR</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.<br /><searchLink fieldCode="AU" term="%22Ussher+JR%22">Ussher JR</searchLink>; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada.
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