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New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways.

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Title: New Genomics Discoveries Across the Bipolar Disorder Spectrum Implicate Neurobiological and Developmental Pathways.
Authors: O'Connell KS; Center for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: kevin.oconnell@medisin.uio.no., Adolfsson R; Department of Clinical Sciences, Psychiatry, Umeå University Medical Faculty, Umeå, Sweden., Andlauer TFM; Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Bauer M; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Baune B; Department of Psychiatry, University of Münster, Münster, Germany; Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia., Biernacka JM; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota., Carpiniello B; Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; Unit of Clinical Psychiatry, Department of Medicine, University Hospital Agency of Cagliari, Cagliari, Italy., Cichon S; Department of Biomedicine, University of Basel, Basel, Switzerland; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland; Institute of Neuroscience and Medicine, Research Centre Jülich, Jülich, Germany., Craddock N; National Centre for Mental Health, Cardiff University, Cardiff, United Kingdom., Cuellar-Barboza AB; Department of Psychiatry, Universidad Autónoma de Nuevo León, Monterrey, Mexico; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Degenhardt F; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Duisburg, Germany., Dikeos D; National and Kapodistrian University of Athens, 1st Department of Psychiatry, Eginition Hospital, Athens, Greece., Ferentinos P; National and Kapodistrian University of Athens, 2nd Department of Psychiatry, Attikon General Hospital, Athens, Greece; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom., Forstner AJ; Institute of Neuroscience and Medicine, Research Centre Jülich, Jülich, Germany; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany; Department of Psychiatry, Marburg University, Marburg, Germany., Frye MA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota., Fullerton JM; Neuroscience Research Australia, Sydney, New South Wales, Australia; School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia., Grigoroiu-Serbanescu M; Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania., Guzman-Parra J; Mental Health Department, University Regional Hospital, Biomedicine Institute, Málaga, Spain., Jones L; Three Counties Medical School, University of Worcester, Worcester, United Kingdom., Jonsson L; Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden., Kircher T; Department of Psychiatry, Marburg University, Marburg, Germany., Kogevinas M; ISGlobal, Barcelona, Spain., Landén M; Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Lissowska J; Cancer Epidemiology and Prevention, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Lochner C; South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, Stellenbosch, South Africa., Manchia M; Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; Unit of Clinical Psychiatry, Department of Medicine, University Hospital Agency of Cagliari, Cagliari, Italy; Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada., Mayoral F; Mental Health Department, University Regional Hospital, Biomedicine Institute, Málaga, Spain., McElroy SL; Research Institute, Lindner Center of HOPE, Mason, Ohio., McGregor NW; Human and Systems Genetics Working Group, Department of Genetics, Stellenbosch University, Stellenbosch, South Africa., Meyer-Lindenberg A; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; German Centre for Mental Health, Germany., Mitchell PB; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia., Müller-Myhsok B; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany; Munich Cluster for Systems Neurology, Munich, Germany; University of Liverpool, Liverpool, United Kingdom., Nöthen MM; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany., Patrinos GP; University of Patras, School of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualized Therapy, Patras, Greece; United Arab Emirates University, College of Medicine and Health Sciences, Department of Genetics and Genomics, Al-Ain, Abu Dhabi, United Arab Emirates; United Arab Emirates University, Zayed Center for Health Sciences, Al-Ain, Abu Dhabi, United Arab Emirates; Erasmus University Medical Center, Faculty of Medicine and Health Sciences, Department of Pathology, Clinical Bioinformatics unit, Rotterdam, the Netherlands., Pawlak JM; Department of Psychiatry, Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznań, Poland., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt am Main, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany., Rietschel M; Department of Psychiatry and Behavioral Sciences, Norton College of Medicine, State University of New York Upstate Medical University, Syracuse, New York., Schofield PR; Discipline of Psychiatry and Mental Health, School of Clinical Medicine, Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia., Schulze TG; Department of Psychiatry and Behavioral Sciences, Norton College of Medicine, State University of New York Upstate Medical University, Syracuse, New York; Institute of Psychiatric Phenomics and Genomics, Ludwig Maximilian University of Munich University Hospital, Ludwig Maximilian University of Munich, Munich, Germany; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland., Serretti A; Department of Medicine and Surgery, Kore University of Enna, Enna, Italy; Oasi Research Institute, Istituto di Ricovero e Cura a Carattere Scientifico, Troina, Italy., Smoller JW; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts., Squassina A; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy., Stein DJ; South African Medical Research Council Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa., Streit F; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt am Main, Germany; Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; German Center for Mental Health, Partner Site Mannheim-Heidelberg-Ulm, Germany., Świątkowska B; Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland., Tondo L; Lucio Bini Mood Disorder Center, Cagliari, Italy; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts., Vieta E; Institute of Neuroscience, University of Barcelona, Barcelona, Spain; Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; CIBERSAM, Barcelona, Spain., Waldman ID; Department of Psychology, Emory University, Atlanta, Georgia., Dale AM; Multimodal Imaging Laboratory, University of California San Diego, La Jolla, California; Center for Multimodal Imaging and Genetics, J. Craig Venter Institute, La Jolla, California., Andreassen OA; Center for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway; KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway. Electronic address: o.a.andreassen@medisin.uio.no.
Corporate Authors: Bipolar Disorder Working Group of the Psychiatric Genomics Consortium
Source: Biological psychiatry [Biol Psychiatry] 2025 Aug 15; Vol. 98 (4), pp. 302-310. Date of Electronic Publication: 2025 May 31.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE
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Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota.<br /><searchLink fieldCode="AU" term="%22Carpiniello+B%22">Carpiniello B</searchLink>; Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; Unit of Clinical Psychiatry, Department of Medicine, University Hospital Agency of Cagliari, Cagliari, Italy.<br /><searchLink fieldCode="AU" term="%22Cichon+S%22">Cichon S</searchLink>; Department of Biomedicine, University of Basel, Basel, Switzerland; Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland; Institute of Neuroscience and Medicine, Research Centre Jülich, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Craddock+N%22">Craddock N</searchLink>; National Centre for Mental Health, Cardiff University, Cardiff, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Cuellar-Barboza+AB%22">Cuellar-Barboza AB</searchLink>; 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      – PersonEntity:
          Name:
            NameFull: McGregor NW
      – PersonEntity:
          Name:
            NameFull: Meyer-Lindenberg A
      – PersonEntity:
          Name:
            NameFull: Mitchell PB
      – PersonEntity:
          Name:
            NameFull: Müller-Myhsok B
      – PersonEntity:
          Name:
            NameFull: Nöthen MM
      – PersonEntity:
          Name:
            NameFull: Patrinos GP
      – PersonEntity:
          Name:
            NameFull: Pawlak JM
      – PersonEntity:
          Name:
            NameFull: Reif A
      – PersonEntity:
          Name:
            NameFull: Rietschel M
      – PersonEntity:
          Name:
            NameFull: Schofield PR
      – PersonEntity:
          Name:
            NameFull: Schulze TG
      – PersonEntity:
          Name:
            NameFull: Serretti A
      – PersonEntity:
          Name:
            NameFull: Smoller JW
      – PersonEntity:
          Name:
            NameFull: Squassina A
      – PersonEntity:
          Name:
            NameFull: Stein DJ
      – PersonEntity:
          Name:
            NameFull: Streit F
      – PersonEntity:
          Name:
            NameFull: Świątkowska B
      – PersonEntity:
          Name:
            NameFull: Tondo L
      – PersonEntity:
          Name:
            NameFull: Vieta E
      – PersonEntity:
          Name:
            NameFull: Waldman ID
      – PersonEntity:
          Name:
            NameFull: Dale AM
      – PersonEntity:
          Name:
            NameFull: Andreassen OA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 15
              M: 08
              Text: 2025 Aug 15
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 1873-2402
          Numbering:
            – Type: volume
              Value: 98
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Biological psychiatry
              Type: main
ResultId 1