Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors.
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| Title: | Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors. |
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| Authors: | Swensen AC; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Piehowski PD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Chen J; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.; Department of Infectious Disease and Immunology, University of Florida, Gainesville, FL, USA., Chan XY; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Kelly SS; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Petyuk VA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Moore RJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Nasif L; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA., Butterworth EA; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA., Atkinson MA; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA., Kulkarni RN; Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center; Department of Medicine, Beth Israel Deaconess Medical Center; Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA., Campbell-Thompson M; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA., Mathews CE; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA. cxm@ufl.edu.; Department of Infectious Disease and Immunology, University of Florida, Gainesville, FL, USA. cxm@ufl.edu., Qian WJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. Weijun.qian@pnnl.gov. |
| Source: | Diabetologia [Diabetologia] 2025 Jul; Vol. 68 (7), pp. 1463-1475. Date of Electronic Publication: 2025 Jun 02. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1432-0428 |
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| DOI: | 10.1007/s00125-025-06417-3 |
