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Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors.

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Title: Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors.
Authors: Swensen AC; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Piehowski PD; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Chen J; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.; Department of Infectious Disease and Immunology, University of Florida, Gainesville, FL, USA., Chan XY; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Kelly SS; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Petyuk VA; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Moore RJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Nasif L; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA., Butterworth EA; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA., Atkinson MA; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA., Kulkarni RN; Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center; Department of Medicine, Beth Israel Deaconess Medical Center; Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA., Campbell-Thompson M; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA., Mathews CE; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA. cxm@ufl.edu.; Department of Infectious Disease and Immunology, University of Florida, Gainesville, FL, USA. cxm@ufl.edu., Qian WJ; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. Weijun.qian@pnnl.gov.
Source: Diabetologia [Diabetologia] 2025 Jul; Vol. 68 (7), pp. 1463-1475. Date of Electronic Publication: 2025 Jun 02.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors.
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  Data: <searchLink fieldCode="AU" term="%22Swensen+AC%22">Swensen AC</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Piehowski+PD%22">Piehowski PD</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.; Department of Infectious Disease and Immunology, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Chan+XY%22">Chan XY</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Kelly+SS%22">Kelly SS</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Petyuk+VA%22">Petyuk VA</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Moore+RJ%22">Moore RJ</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Nasif+L%22">Nasif L</searchLink>; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Butterworth+EA%22">Butterworth EA</searchLink>; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Atkinson+MA%22">Atkinson MA</searchLink>; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Kulkarni+RN%22">Kulkarni RN</searchLink>; Section of Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center; Department of Medicine, Beth Israel Deaconess Medical Center; Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Campbell-Thompson+M%22">Campbell-Thompson M</searchLink>; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Mathews+CE%22">Mathews CE</searchLink>; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA. cxm@ufl.edu.; Department of Infectious Disease and Immunology, University of Florida, Gainesville, FL, USA. cxm@ufl.edu.<br /><searchLink fieldCode="AU" term="%22Qian+WJ%22">Qian WJ</searchLink>; Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA. Weijun.qian@pnnl.gov.
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  Data: <searchLink fieldCode="JN" term="%220006777%22">Diabetologia</searchLink> [Diabetologia] 2025 Jul; Vol. 68 (7), pp. 1463-1475. <i>Date of Electronic Publication: </i>2025 Jun 02.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0006777 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0428 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220012186X%22">0012186X </searchLink><i>NLM ISO Abbreviation: </i>Diabetologia <i>Subsets: </i>MEDLINE
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              Text: 2025 Jul
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