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Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations.

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Title: Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations.
Authors: Dreyer FA; Exscientia, Oxford Science Park, Oxford, UK., Schneider C; Exscientia, Oxford Science Park, Oxford, UK., Kovaltsuk A; Exscientia, Oxford Science Park, Oxford, UK., Cutting D; Exscientia, Oxford Science Park, Oxford, UK., Byrne MJ; Exscientia, Oxford Science Park, Oxford, UK., Nissley DA; Exscientia, Oxford Science Park, Oxford, UK., Kenlay H; Exscientia, Oxford Science Park, Oxford, UK., Marks C; Exscientia, Oxford Science Park, Oxford, UK., Errington D; Exscientia, Oxford Science Park, Oxford, UK., Gildea RJ; Exscientia, Oxford Science Park, Oxford, UK., Damerell D; Exscientia, Oxford Science Park, Oxford, UK., Tizei P; Exscientia, Oxford Science Park, Oxford, UK., Bunjobpol W; Exscientia, Oxford Science Park, Oxford, UK., Darby JF; Exscientia, Oxford Science Park, Oxford, UK., Drulyte I; Materials and Structural Analysis, Thermo Fisher Scientific, Eindhoven, Netherlands., Hurdiss DL; Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands., Surade S; Exscientia, Oxford Science Park, Oxford, UK., Wahome N; Exscientia, Oxford Science Park, Oxford, UK., Pires DEV; Exscientia, Oxford Science Park, Oxford, UK., Deane CM; Exscientia, Oxford Science Park, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK.
Source: MAbs [MAbs] 2025 Dec; Vol. 17 (1), pp. 2511220. Date of Electronic Publication: 2025 Jun 03.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101479829 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-0870 (Electronic) Linking ISSN: 19420862 NLM ISO Abbreviation: MAbs Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations.
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