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Bridging in vitro and clinical data: Experimental insights into the IC50 variability of dolutegravir as an organic cation transporter 2 inhibitor.

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Title: Bridging in vitro and clinical data: Experimental insights into the IC50 variability of dolutegravir as an organic cation transporter 2 inhibitor.
Authors: Koishikawa T; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan., Tomoda Y; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan., Tsuchitani T; Faculty of Pharmacy, Keio University, Minato-ku, Tokyo, Japan., Taskar K; Drug Metabolism and Pharmacokinetic, GSK, Stevenage, United Kingdom., Yoshida K; Clinical Pharmacology, Genentech, Inc., South San Francisco, California., Mao J; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California., Takashima T; Laboratory for Safety Assessment & ADME, Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation, Shizuoka, Japan., Lai Y; Drug Metabolism Department, Gilead Sciences Inc, Foster City, California., Sugiyama Y; Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, Innovation Base, Josai International University, Tokyo, Japan., Kusuhara H; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan. Electronic address: kusuhara@mol.f.u-tokyo.ac.jp.
Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2025 Jun; Vol. 53 (6), pp. 100087. Date of Electronic Publication: 2025 Apr 28.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Bridging in vitro and clinical data: Experimental insights into the IC<subscript>50</subscript> variability of dolutegravir as an organic cation transporter 2 inhibitor.
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  Data: <searchLink fieldCode="AU" term="%22Koishikawa+T%22">Koishikawa T</searchLink>; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tomoda+Y%22">Tomoda Y</searchLink>; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tsuchitani+T%22">Tsuchitani T</searchLink>; Faculty of Pharmacy, Keio University, Minato-ku, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Taskar+K%22">Taskar K</searchLink>; Drug Metabolism and Pharmacokinetic, GSK, Stevenage, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Yoshida+K%22">Yoshida K</searchLink>; Clinical Pharmacology, Genentech, Inc., South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Mao+J%22">Mao J</searchLink>; Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Takashima+T%22">Takashima T</searchLink>; Laboratory for Safety Assessment & ADME, Pharmaceuticals Research Center, Asahi Kasei Pharma Corporation, Shizuoka, Japan.<br /><searchLink fieldCode="AU" term="%22Lai+Y%22">Lai Y</searchLink>; Drug Metabolism Department, Gilead Sciences Inc, Foster City, California.<br /><searchLink fieldCode="AU" term="%22Sugiyama+Y%22">Sugiyama Y</searchLink>; Laboratory of Quantitative System Pharmacokinetics/Pharmacodynamics, Innovation Base, Josai International University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kusuhara+H%22">Kusuhara H</searchLink>; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan. Electronic address: kusuhara@mol.f.u-tokyo.ac.jp.
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              Text: 2025 Jun
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