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Simvastatin as Add-On Treatment to Escitalopram in Patients With Major Depression and Obesity: A Randomized Clinical Trial.

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Title: Simvastatin as Add-On Treatment to Escitalopram in Patients With Major Depression and Obesity: A Randomized Clinical Trial.
Authors: Otte C; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Mental Health partner site Berlin/Potsdam, Germany., Chae WR; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Mental Health partner site Berlin/Potsdam, Germany.; Berlin Institute of Health at Charité Universitätsmedizin Berlin, Berlin, Germany., Dogan DY; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany., Piber D; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité Universitätsmedizin Berlin, Berlin, Germany., Roepke S; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany., Cho AB; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité Universitätsmedizin Berlin, Berlin, Germany., Trumm S; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany., Kaczmarczyk M; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany., Brasanac J; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany., Wingenfeld K; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Mental Health partner site Berlin/Potsdam, Germany., Koglin S; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany., Wieditz J; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany., Junghanns K; Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany., Lucht M; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Prvulovic D; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Medical Centre Frankfurt, Frankfurt am Main, Germany., Krüger THC; Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hanover, Germany.; Centre for Systems Neuroscience Hannover, Hanover, Germany., Terock J; Department of Psychiatry and Psychotherapy, Helios Hanseklinikum Stralsund, Stralsund, Germany., Haaf M; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hofmann T; German Center for Mental Health partner site Berlin/Potsdam, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Humboldt-Universität zu Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, Center for Patient-Centered Outcomes Research, Berlin, Germany.; Department of Psychosomatic Medicine and Psychotherapy, DRK Kliniken Berlin Wiegmann Klinik, Berlin, Germany., Mauche N; Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany., Klein JP; Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Reif A; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Medical Centre Frankfurt, Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany., Kahl KG; Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hanover, Germany., Janowitz D; Department of Psychiatry and Psychotherapy, Helios Hanseklinikum Stralsund, Stralsund, Germany., Leicht G; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hinkelmann K; German Center for Mental Health partner site Berlin/Potsdam, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Humboldt-Universität zu Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, Center for Patient-Centered Outcomes Research, Berlin, Germany., Strauß M; Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany., Friede T; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany., Gold SM; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Mental Health partner site Berlin/Potsdam, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Humboldt-Universität zu Berlin, Berlin, Germany.; Institute of Neuroimmunology and Multiple Sclerosis, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Source: JAMA psychiatry [JAMA Psychiatry] 2025 Aug 01; Vol. 82 (8), pp. 759-767.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589550 Publication Model: Print Cited Medium: Internet ISSN: 2168-6238 (Electronic) Linking ISSN: 2168622X NLM ISO Abbreviation: JAMA Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Simvastatin as Add-On Treatment to Escitalopram in Patients With Major Depression and Obesity: A Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Otte+C%22">Otte C</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Mental Health partner site Berlin/Potsdam, Germany.<br /><searchLink fieldCode="AU" term="%22Chae+WR%22">Chae WR</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Mental Health partner site Berlin/Potsdam, Germany.; Berlin Institute of Health at Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Dogan+DY%22">Dogan DY</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Piber+D%22">Piber D</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Roepke+S%22">Roepke S</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Cho+AB%22">Cho AB</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Trumm+S%22">Trumm S</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kaczmarczyk+M%22">Kaczmarczyk M</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Brasanac+J%22">Brasanac J</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wingenfeld+K%22">Wingenfeld K</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Mental Health partner site Berlin/Potsdam, Germany.<br /><searchLink fieldCode="AU" term="%22Koglin+S%22">Koglin S</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wieditz+J%22">Wieditz J</searchLink>; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Junghanns+K%22">Junghanns K</searchLink>; Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Lucht+M%22">Lucht M</searchLink>; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Prvulovic+D%22">Prvulovic D</searchLink>; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Medical Centre Frankfurt, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Krüger+THC%22">Krüger THC</searchLink>; Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hanover, Germany.; Centre for Systems Neuroscience Hannover, Hanover, Germany.<br /><searchLink fieldCode="AU" term="%22Terock+J%22">Terock J</searchLink>; Department of Psychiatry and Psychotherapy, Helios Hanseklinikum Stralsund, Stralsund, Germany.<br /><searchLink fieldCode="AU" term="%22Haaf+M%22">Haaf M</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hofmann+T%22">Hofmann T</searchLink>; German Center for Mental Health partner site Berlin/Potsdam, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Humboldt-Universität zu Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, Center for Patient-Centered Outcomes Research, Berlin, Germany.; Department of Psychosomatic Medicine and Psychotherapy, DRK Kliniken Berlin Wiegmann Klinik, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Mauche+N%22">Mauche N</searchLink>; Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Klein+JP%22">Klein JP</searchLink>; Department of Psychiatry and Psychotherapy, Lübeck University, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Grabe+HJ%22">Grabe HJ</searchLink>; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Reif+A%22">Reif A</searchLink>; Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Medical Centre Frankfurt, Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Kahl+KG%22">Kahl KG</searchLink>; Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hanover, Germany.<br /><searchLink fieldCode="AU" term="%22Janowitz+D%22">Janowitz D</searchLink>; Department of Psychiatry and Psychotherapy, Helios Hanseklinikum Stralsund, Stralsund, Germany.<br /><searchLink fieldCode="AU" term="%22Leicht+G%22">Leicht G</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hinkelmann+K%22">Hinkelmann K</searchLink>; German Center for Mental Health partner site Berlin/Potsdam, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Humboldt-Universität zu Berlin, Berlin, Germany.; Charité-Universitätsmedizin Berlin, Center for Patient-Centered Outcomes Research, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Strauß+M%22">Strauß M</searchLink>; Department of Psychiatry and Psychotherapy, University of Leipzig Medical Center, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Friede+T%22">Friede T</searchLink>; Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Gold+SM%22">Gold SM</searchLink>; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychiatry and Psychotherapy, Humboldt-Universität zu Berlin, Berlin, Germany.; German Center for Mental Health partner site Berlin/Potsdam, Germany.; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Humboldt-Universität zu Berlin, Berlin, Germany.; Institute of Neuroimmunology and Multiple Sclerosis, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
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