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A phase 1 clinical trial shows safe, sustained, AAV-mediated expression of IL-1Ra in the human osteoarthritic knee joint.

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Title: A phase 1 clinical trial shows safe, sustained, AAV-mediated expression of IL-1Ra in the human osteoarthritic knee joint.
Authors: De la Vega RE; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA.; Musculoskeletal Gene Therapy Laboratory, Mayo Clinic, Rochester, MN 55905, USA., Sellon JL; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA., Smith J; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA., Wisniewski SJ; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA., Jurisson ML; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA., Frick MA; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA., Scrabeck TL; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA., Block JB; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA., Mills CJ; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA., Pohlkamp ZW; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA., Coenen MJ; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Musculoskeletal Gene Therapy Laboratory, Mayo Clinic, Rochester, MN 55905, USA., Hawse GP; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Musculoskeletal Gene Therapy Laboratory, Mayo Clinic, Rochester, MN 55905, USA., Abdul TY; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Musculoskeletal Gene Therapy Laboratory, Mayo Clinic, Rochester, MN 55905, USA.; Department of Clinical Pharmacology, Mayo Clinic, Rochester, MN 55905, USA., Conaghan P; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds LS7 4SA, UK., Keravala A; Genascence Corp., Palo Alto, CA 94306, USA., Chalberg TW; Genascence Corp., Palo Alto, CA 94306, USA., Robbins PD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA., Ghivizzani SC; Department of Orthopedics and Rehabilitation, University of Florida College of Medicine, Gainesville, FL 32610, USA., Evans CH; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA.; Musculoskeletal Gene Therapy Laboratory, Mayo Clinic, Rochester, MN 55905, USA.; Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Source: Science translational medicine [Sci Transl Med] 2025 Jun 04; Vol. 17 (801), pp. eadu9804. Date of Electronic Publication: 2025 Jun 04.
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A phase 1 clinical trial shows safe, sustained, AAV-mediated expression of IL-1Ra in the human osteoarthritic knee joint.
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  Data: <searchLink fieldCode="AU" term="%22De+la+Vega+RE%22">De la Vega RE</searchLink>; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA.; Musculoskeletal Gene Therapy Laboratory, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Sellon+JL%22">Sellon JL</searchLink>; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Smith+J%22">Smith J</searchLink>; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Wisniewski+SJ%22">Wisniewski SJ</searchLink>; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Jurisson+ML%22">Jurisson ML</searchLink>; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Frick+MA%22">Frick MA</searchLink>; Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Scrabeck+TL%22">Scrabeck TL</searchLink>; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Block+JB%22">Block JB</searchLink>; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Mills+CJ%22">Mills CJ</searchLink>; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Pohlkamp+ZW%22">Pohlkamp ZW</searchLink>; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Coenen+MJ%22">Coenen MJ</searchLink>; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Musculoskeletal Gene Therapy Laboratory, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Hawse+GP%22">Hawse GP</searchLink>; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Musculoskeletal Gene Therapy Laboratory, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Abdul+TY%22">Abdul TY</searchLink>; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Musculoskeletal Gene Therapy Laboratory, Mayo Clinic, Rochester, MN 55905, USA.; Department of Clinical Pharmacology, Mayo Clinic, Rochester, MN 55905, USA.<br /><searchLink fieldCode="AU" term="%22Conaghan+P%22">Conaghan P</searchLink>; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds LS7 4SA, UK.<br /><searchLink fieldCode="AU" term="%22Keravala+A%22">Keravala A</searchLink>; Genascence Corp., Palo Alto, CA 94306, USA.<br /><searchLink fieldCode="AU" term="%22Chalberg+TW%22">Chalberg TW</searchLink>; Genascence Corp., Palo Alto, CA 94306, USA.<br /><searchLink fieldCode="AU" term="%22Robbins+PD%22">Robbins PD</searchLink>; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.<br /><searchLink fieldCode="AU" term="%22Ghivizzani+SC%22">Ghivizzani SC</searchLink>; Department of Orthopedics and Rehabilitation, University of Florida College of Medicine, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Evans+CH%22">Evans CH</searchLink>; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN 55905, USA.; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA.; Musculoskeletal Gene Therapy Laboratory, Mayo Clinic, Rochester, MN 55905, USA.; Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2025 Jun 04; Vol. 17 (801), pp. eadu9804. <i>Date of Electronic Publication: </i>2025 Jun 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101505086 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1946-6242 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219466234%22">19466234 </searchLink><i>NLM ISO Abbreviation: </i>Sci Transl Med <i>Subsets: </i>MEDLINE
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