Redox signaling-mediated S-glutathionylation of protein disulfide isomerase A1 initiates intrinsic apoptosis and contributes to accelerated aging.

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Title: Redox signaling-mediated S-glutathionylation of protein disulfide isomerase A1 initiates intrinsic apoptosis and contributes to accelerated aging.
Authors: Ye ZW; Department of Pharmacology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC29425, USA., Zhang J; Department of Pharmacology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC29425, USA., Kumar A; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, NY14203, USA., Huang X; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, NY14203, USA., Mathuram TL; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, NY14203, USA., Mccall AD; Confocal Microscopy Facility, School of Dental Medicine, University at Buffalo, NY14215, USA., Culpepper J; Department of Pharmacology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC29425, USA., Zhang L; Department of Pharmacology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC29425, USA., Curione AD; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, NY14203, USA., Xu J; School of Life and Pharmaceutical Sciences (LPS) and Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin, China., Tew KD; Department of Pharmacology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC29425, USA., Townsend DM; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, SC29425, USA. Electronic address: townsed@musc.edu., Blumental-Perry A; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, NY14203, USA. Electronic address: annablum@buffalo.edu.
Source: Redox biology [Redox Biol] 2025 Sep; Vol. 85, pp. 103680. Date of Electronic Publication: 2025 May 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Redox signaling-mediated S-glutathionylation of protein disulfide isomerase A1 initiates intrinsic apoptosis and contributes to accelerated aging.
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  Data: <searchLink fieldCode="AU" term="%22Ye+ZW%22">Ye ZW</searchLink>; Department of Pharmacology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC29425, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Pharmacology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC29425, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+A%22">Kumar A</searchLink>; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, NY14203, USA.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, NY14203, USA.<br /><searchLink fieldCode="AU" term="%22Mathuram+TL%22">Mathuram TL</searchLink>; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, NY14203, USA.<br /><searchLink fieldCode="AU" term="%22Mccall+AD%22">Mccall AD</searchLink>; Confocal Microscopy Facility, School of Dental Medicine, University at Buffalo, NY14215, USA.<br /><searchLink fieldCode="AU" term="%22Culpepper+J%22">Culpepper J</searchLink>; Department of Pharmacology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC29425, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Pharmacology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC29425, USA.<br /><searchLink fieldCode="AU" term="%22Curione+AD%22">Curione AD</searchLink>; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, NY14203, USA.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; School of Life and Pharmaceutical Sciences (LPS) and Panjin Institute of Industrial Technology (PIIT), Dalian University of Technology, Panjin, China.<br /><searchLink fieldCode="AU" term="%22Tew+KD%22">Tew KD</searchLink>; Department of Pharmacology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC29425, USA.<br /><searchLink fieldCode="AU" term="%22Townsend+DM%22">Townsend DM</searchLink>; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, SC29425, USA. Electronic address: townsed@musc.edu.<br /><searchLink fieldCode="AU" term="%22Blumental-Perry+A%22">Blumental-Perry A</searchLink>; Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, NY14203, USA. Electronic address: annablum@buffalo.edu.
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  Data: <searchLink fieldCode="JN" term="%22101605639%22">Redox biology</searchLink> [Redox Biol] 2025 Sep; Vol. 85, pp. 103680. <i>Date of Electronic Publication: </i>2025 May 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2C+B%2EV%22">Elsevier, B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101605639 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2213-2317 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222132317%22">22132317 </searchLink><i>NLM ISO Abbreviation: </i>Redox Biol <i>Subsets: </i>MEDLINE
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