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Optimization of Inspired Oxygen during Mechanical Ventilation (OPTI-OXYGEN): rationale and design of a pragmatic randomised controlled trial.

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Title: Optimization of Inspired Oxygen during Mechanical Ventilation (OPTI-OXYGEN): rationale and design of a pragmatic randomised controlled trial.
Authors: Pannu SR; Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio, USA.; Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA., Peters J; Department of Respiratory Therapy, The Ohio State University, Columbus, Ohio, USA jp537421@ohio.edu.; Ohio University Heritage College of Osteopathic Medicine Dublin Campus, Dublin, Ohio, USA., Zimmer J; Department of Respiratory Therapy, The Ohio State University, Columbus, Ohio, USA., Brock GN; Center for Biostatistics, The Ohio State University, Columbus, Ohio, USA., Exline M; Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio, USA.; Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA., Horowitz JC; Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio, USA.; Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA., Thompson TB; Department of Medicine, Pulmonary and Critical Care Unit, Massachusetts General Hospital Institute for Patient Care, Boston, Massachusetts, USA., Rice TW; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Crouser ED; Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio, USA.; Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Source: BMJ open [BMJ Open] 2025 Jun 05; Vol. 15 (6), pp. e094924. Date of Electronic Publication: 2025 Jun 05.
Publication Type: Clinical Trial Protocol; Journal Article
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Pannu+SR%22">Pannu SR</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio, USA.; Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Peters+J%22">Peters J</searchLink>; Department of Respiratory Therapy, The Ohio State University, Columbus, Ohio, USA jp537421@ohio.edu.; Ohio University Heritage College of Osteopathic Medicine Dublin Campus, Dublin, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Zimmer+J%22">Zimmer J</searchLink>; Department of Respiratory Therapy, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Brock+GN%22">Brock GN</searchLink>; Center for Biostatistics, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Exline+M%22">Exline M</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio, USA.; Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Horowitz+JC%22">Horowitz JC</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio, USA.; Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Thompson+TB%22">Thompson TB</searchLink>; Department of Medicine, Pulmonary and Critical Care Unit, Massachusetts General Hospital Institute for Patient Care, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Rice+TW%22">Rice TW</searchLink>; Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Crouser+ED%22">Crouser ED</searchLink>; Division of Pulmonary, Critical Care and Sleep Medicine, The Ohio State University, Columbus, Ohio, USA.; Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
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              Text: 2025 Jun 05
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