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Multi-omic spatial profiling reveals the unique SARS-CoV-2 lung microenvironment and collagen VI as a predictive biomarker in severe COVID-19.

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Title: Multi-omic spatial profiling reveals the unique SARS-CoV-2 lung microenvironment and collagen VI as a predictive biomarker in severe COVID-19.
Authors: Fennell É; School of Medicine, University of Limerick, Limerick, Ireland.; Bernal Institute, University of Limerick, Limerick, Ireland.; Limerick Digital Cancer Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland.; É. Fennell and G.S. Taylor contributed equally to this work., Taylor GS; Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; É. Fennell and G.S. Taylor contributed equally to this work., Leahy CI; School of Medicine, University of Limerick, Limerick, Ireland.; Bernal Institute, University of Limerick, Limerick, Ireland.; Limerick Digital Cancer Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland., Ross AM; School of Medicine, University of Limerick, Limerick, Ireland.; Bernal Institute, University of Limerick, Limerick, Ireland.; Limerick Digital Cancer Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland., Reynolds G; Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK., Perry T; Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK., Youd E; Forensic Medicine and Science, University of Glasgow, Glasgow, UK., Skidmore J; Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK., Darwish RRR; School of Medicine, University of Limerick, Limerick, Ireland.; Bernal Institute, University of Limerick, Limerick, Ireland.; Limerick Digital Cancer Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland.; School of Medicine, Royal College of Surgeons in Ireland - Medical University of Bahrain, Adliya, Bahrain., Hunter KJ; Birmingham Tissue Analytics, University of Birmingham, Birmingham, UK., Willcox BE; Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Birmingham Tissue Analytics, University of Birmingham, Birmingham, UK., Jermann P; Department of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Arif Jahangir C; School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland., Rahman A; School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland., Gallagher WM; School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland., Nikulina N; Institute of Lung Health, Justus Liebig University Giessen, Giessen, Germany., Ben Cheikh B; Akoya Biosciences, Marlborough, MA, USA., Braubach O; Bruker Spatial Biology, St Louis, MO, USA., Mayer AT; Enable Medicine, Menlo Park, CA, USA., Young LS; Warwick Medical School, University of Warwick, Coventry, UK., Grammatopoulos D; Warwick Medical School, University of Warwick, Coventry, UK., Faustini S; Clinical Immunology Service, University of Birmingham, Birmingham, UK., Richter A; Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; Clinical Immunology Service, University of Birmingham, Birmingham, UK., Dowell AC; Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK., Venith T; Department of Critical Care and Anaesthesia, Queen Elizabeth Hospital Birmingham, Birmingham, UK., Thein OS; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Parekh D; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Belchamber KBR; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Thickett DR; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Scott A; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK., Attanoos R; Department of Pathology, University Hospital of Wales, Cardiff, UK., Mundo L; Section of Pathology, Department of Medical Biotechnologies, University of Siena, Siena, Italy., Lazzi S; Section of Pathology, Department of Medical Biotechnologies, University of Siena, Siena, Italy., Leoncini L; Section of Pathology, Department of Medical Biotechnologies, University of Siena, Siena, Italy., Leopold G; Department of Cellular Pathology, Swansea Bay University Health Board, Swansea, UK., Steven N; Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK., Bülow Sand JM; Nordic Bioscience, Herlev, Denmark., Karsdal MA; Nordic Bioscience, Herlev, Denmark., Leeming DJ; Nordic Bioscience, Herlev, Denmark., Dojcinov S; Department of Cellular Pathology, Swansea Bay University Health Board, Swansea, UK., Culhane A; School of Medicine, University of Limerick, Limerick, Ireland.; Limerick Digital Cancer Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland.; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Murray PG; School of Medicine, University of Limerick, Limerick, Ireland.; Bernal Institute, University of Limerick, Limerick, Ireland.; Limerick Digital Cancer Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland.; School of Medicine, Royal College of Surgeons in Ireland - Medical University of Bahrain, Adliya, Bahrain.; P.G. Murray and M.R. Pugh contributed equally to this work., Pugh MR; Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK M.Pugh.1@bham.ac.uk.; P.G. Murray and M.R. Pugh contributed equally to this work.
Source: The European respiratory journal [Eur Respir J] 2025 Sep 17; Vol. 66 (3). Date of Electronic Publication: 2025 Sep 17 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1399-3003 (Electronic) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Fennell+É%22">Fennell É</searchLink>; School of Medicine, University of Limerick, Limerick, Ireland.; Bernal Institute, University of Limerick, Limerick, Ireland.; Limerick Digital Cancer Research Centre, Health Research Institute, University of Limerick, Limerick, Ireland.; É. Fennell and G.S. Taylor contributed equally to this work.<br /><searchLink fieldCode="AU" term="%22Taylor+GS%22">Taylor GS</searchLink>; Department of Immunology and Immunotherapy, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK.; É. Fennell and G.S. 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