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Utility of plasma GFAP as a secondary endpoint for clinical trials in Alzheimer's disease.

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Title: Utility of plasma GFAP as a secondary endpoint for clinical trials in Alzheimer's disease.
Authors: Abbas S; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Ferreira PCL; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Bellaver B; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Povala G; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Rohden F; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Aguzzoli CS; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Brain Institute of Rio Grande do Sul, PUCRS, 6690 Ipiranga Avenue, 90610-000, Porto Alegre, RS, Brazil., Zalzale H; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Ferrari-Souza JP; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Leffa DT; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Lussier FZ; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Soares C; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Bauer-Negrini G; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Oliveira-Junior MS; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Rodrigues MS; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Saha P; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Ruppert E; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Medeiros MS; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Tissot C; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Canada; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada; Department of Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Therriault J; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Canada; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada., Rahmouni N; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Canada., Servaes S; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Canada., Benedet AL; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden., Ashton NJ; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Tudorascu DL; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Gauthier S; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada., Karim H; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA., Hong CH; Department of Psychiatry, Ajou University School of Medicine, Suwon, Republic of Korea, South Korea., Roh HW; Department of Psychiatry, Ajou University School of Medicine, Suwon, Republic of Korea, South Korea., Zimmer ER; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Brain Institute of Rio Grande do Sul, PUCRS, 6690 Ipiranga Avenue, 90610-000, Porto Alegre, RS, Brazil; Department of Pharmacology, Universidade Federal do Rio Grande do Sul (UFRGS), 2500 Ramiro Barcelos Street, 90035-003, Porto Alegre, RS, Brazil; Graduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul (UFRGS), 2500 Ramiro Barcelos Street, 90035-003, Porto Alegre, RS, Brazil., Karikari TK; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden., Zetterberg H; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK; UK Dementia Research Institute at UCL, London, UK; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China., Blennow K; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden., Saeed A; Department of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA., Son SJ; Department of Psychiatry, Ajou University School of Medicine, Suwon, Republic of Korea, South Korea., Rosa-Neto P; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Canada; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada., Pascoal T; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: pascoalt@upmc.edu.
Corporate Authors: for Alzheimer’s Disease Neuroimaging Initiative
Source: The journal of prevention of Alzheimer's disease [J Prev Alzheimers Dis] 2025 Aug; Vol. 12 (7), pp. 100205. Date of Electronic Publication: 2025 Jun 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101638820 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2426-0266 (Electronic) Linking ISSN: 22745807 NLM ISO Abbreviation: J Prev Alzheimers Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Abbas+S%22">Abbas S</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ferreira+PCL%22">Ferreira PCL</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bellaver+B%22">Bellaver B</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Povala+G%22">Povala G</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rohden+F%22">Rohden F</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Aguzzoli+CS%22">Aguzzoli CS</searchLink>; 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Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tissot+C%22">Tissot C</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Canada; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada; Department of Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Therriault+J%22">Therriault J</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Canada; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Rahmouni+N%22">Rahmouni N</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Servaes+S%22">Servaes S</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Canada.<br /><searchLink fieldCode="AU" term="%22Benedet+AL%22">Benedet AL</searchLink>; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Ashton+NJ%22">Ashton NJ</searchLink>; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tudorascu+DL%22">Tudorascu DL</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gauthier+S%22">Gauthier S</searchLink>; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Karim+H%22">Karim H</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hong+CH%22">Hong CH</searchLink>; Department of Psychiatry, Ajou University School of Medicine, Suwon, Republic of Korea, South Korea.<br /><searchLink fieldCode="AU" term="%22Roh+HW%22">Roh HW</searchLink>; Department of Psychiatry, Ajou University School of Medicine, Suwon, Republic of Korea, South Korea.<br /><searchLink fieldCode="AU" term="%22Zimmer+ER%22">Zimmer ER</searchLink>; Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Brain Institute of Rio Grande do Sul, PUCRS, 6690 Ipiranga Avenue, 90610-000, Porto Alegre, RS, Brazil; Department of Pharmacology, Universidade Federal do Rio Grande do Sul (UFRGS), 2500 Ramiro Barcelos Street, 90035-003, Porto Alegre, RS, Brazil; Graduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul (UFRGS), 2500 Ramiro Barcelos Street, 90035-003, Porto Alegre, RS, Brazil.<br /><searchLink fieldCode="AU" term="%22Karikari+TK%22">Karikari TK</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.<br /><searchLink fieldCode="AU" term="%22Zetterberg+H%22">Zetterberg H</searchLink>; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK; UK Dementia Research Institute at UCL, London, UK; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Blennow+K%22">Blennow K</searchLink>; Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Saeed+A%22">Saeed A</searchLink>; Department of Cardiology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Son+SJ%22">Son SJ</searchLink>; Department of Psychiatry, Ajou University School of Medicine, Suwon, Republic of Korea, South Korea.<br /><searchLink fieldCode="AU" term="%22Rosa-Neto+P%22">Rosa-Neto P</searchLink>; Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Alzheimer's Disease Research Unit, Douglas Research Institute, Le Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Ouest-de-l'Île-de-Montréal, Canada; Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Pascoal+T%22">Pascoal T</searchLink>; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: pascoalt@upmc.edu.
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