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Effect of preoperative rapamycin supplementation on perioperative clinical frailty and cognitive performance in a murine model undergoing anesthesia and surgery.

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Title: Effect of preoperative rapamycin supplementation on perioperative clinical frailty and cognitive performance in a murine model undergoing anesthesia and surgery.
Authors: Sim MA; Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ming_ann_sim@Nuhs.edu.sg.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ming_ann_sim@Nuhs.edu.sg.; Department of Anesthesia, National University Health System, Singapore, Singapore. ming_ann_sim@Nuhs.edu.sg., Goh J; Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lee J; Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Tay JH; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Academy for Healthy Longevity and Healthy Longevity Translational Research Programme, National University of Singapore, Singapore, Singapore., Tan FCK; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Li C; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Wong ESP; Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Loh WNH; Department of Anesthesia, National University Health System, Singapore, Singapore., Chew STH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Anesthesia, Singapore General Hospital, Singapore, Singapore., Maier AB; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Academy for Healthy Longevity and Healthy Longevity Translational Research Programme, National University of Singapore, Singapore, Singapore.; Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands., Kennedy BK; Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ti LK; Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. anatilk@nus.edu.sg.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. anatilk@nus.edu.sg.; Department of Anesthesia, National University Health System, Singapore, Singapore. anatilk@nus.edu.sg.
Source: Scientific reports [Sci Rep] 2025 Jun 05; Vol. 15 (1), pp. 19741. Date of Electronic Publication: 2025 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Sim+MA%22">Sim MA</searchLink>; Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ming_ann_sim@Nuhs.edu.sg.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ming_ann_sim@Nuhs.edu.sg.; Department of Anesthesia, National University Health System, Singapore, Singapore. ming_ann_sim@Nuhs.edu.sg.<br /><searchLink fieldCode="AU" term="%22Goh+J%22">Goh J</searchLink>; Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tay+JH%22">Tay JH</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Academy for Healthy Longevity and Healthy Longevity Translational Research Programme, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+FCK%22">Tan FCK</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Wong+ESP%22">Wong ESP</searchLink>; Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Loh+WNH%22">Loh WNH</searchLink>; Department of Anesthesia, National University Health System, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chew+STH%22">Chew STH</searchLink>; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Anesthesia, Singapore General Hospital, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Maier+AB%22">Maier AB</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; NUS Academy for Healthy Longevity and Healthy Longevity Translational Research Programme, National University of Singapore, Singapore, Singapore.; Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kennedy+BK%22">Kennedy BK</searchLink>; Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ti+LK%22">Ti LK</searchLink>; Centre for Healthy Longevity, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. anatilk@nus.edu.sg.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. anatilk@nus.edu.sg.; Department of Anesthesia, National University Health System, Singapore, Singapore. anatilk@nus.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2025 Jun 05; Vol. 15 (1), pp. 19741. <i>Date of Electronic Publication: </i>2025 Jun 05.
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        Value: 10.1038/s41598-025-02707-3
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