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In vivo CRISPR screening identifies NF1/RASA1/TP53 co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesis.

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Title: In vivo CRISPR screening identifies NF1/RASA1/TP53 co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesis.
Authors: Vu K; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA., Gunti S; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA., Viswanathan R; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA., Nandal A; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA., Larkin R; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.; Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center; Nashville, TN, USA., Cho S; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA., Zou J; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA., Ramolia S; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA., Hoke ATK; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.; Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center; Nashville, TN, USA., Barbosa SM; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA., Gallia GL; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine; Baltimore, MD, USA.; Department of Neurosurgery, Johns Hopkins University School of Medicine; Baltimore, MD, USA., Rooper LM; Department of Pathology, Johns Hopkins University School of Medicine; Baltimore, MD, USA., Floudas CS; Center for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA., Cheng H; National Institute of Deafness and Other Communication Disorders, National Institutes of Health; Bethesda, MD, USA., Miller CN; Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research; Frederick, MD, USA., Guest MR; Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research; Frederick, MD, USA., Notaro M; enGene Statistics GmbH, Basel, Switzerland., Raziuddin A; Genomics Technology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA., Sun Z; Genomics Technology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA., Wu X; Genomics Technology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA., Faraji F; Division of Surgery, Division of Otolaryngology - Head and Neck Surgery, University of California San Diego Health; La Jolla, CA, USA., Lechner M; Division of Surgery and Interventional Science, University College London; London, United Kingdom., Comoglio F; enGene Statistics GmbH, Basel, Switzerland., Edmondson EF; Molecular Histopathology Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research; Frederick, MD, USA., Chari R; Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research; Frederick, MD, USA., London NR Jr; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine; Baltimore, MD, USA.; Department of Neurosurgery, Johns Hopkins University School of Medicine; Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University School of Medicine; Baltimore, MD, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 24. Date of Electronic Publication: 2025 Jun 24.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: In vivo CRISPR screening identifies NF1/RASA1/TP53 co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesis.
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  Data: <searchLink fieldCode="AU" term="%22Vu+K%22">Vu K</searchLink>; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gunti+S%22">Gunti S</searchLink>; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Viswanathan+R%22">Viswanathan R</searchLink>; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Nandal+A%22">Nandal A</searchLink>; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Larkin+R%22">Larkin R</searchLink>; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.; Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center; Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Cho+S%22">Cho S</searchLink>; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Zou+J%22">Zou J</searchLink>; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ramolia+S%22">Ramolia S</searchLink>; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hoke+ATK%22">Hoke ATK</searchLink>; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.; Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center; Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Barbosa+SM%22">Barbosa SM</searchLink>; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gallia+GL%22">Gallia GL</searchLink>; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine; Baltimore, MD, USA.; Department of Neurosurgery, Johns Hopkins University School of Medicine; Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rooper+LM%22">Rooper LM</searchLink>; Department of Pathology, Johns Hopkins University School of Medicine; Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Floudas+CS%22">Floudas CS</searchLink>; Center for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cheng+H%22">Cheng H</searchLink>; National Institute of Deafness and Other Communication Disorders, National Institutes of Health; Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Miller+CN%22">Miller CN</searchLink>; Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research; Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Guest+MR%22">Guest MR</searchLink>; Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research; Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Notaro+M%22">Notaro M</searchLink>; enGene Statistics GmbH, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Raziuddin+A%22">Raziuddin A</searchLink>; Genomics Technology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sun+Z%22">Sun Z</searchLink>; Genomics Technology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Genomics Technology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Faraji+F%22">Faraji F</searchLink>; Division of Surgery, Division of Otolaryngology - Head and Neck Surgery, University of California San Diego Health; La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lechner+M%22">Lechner M</searchLink>; Division of Surgery and Interventional Science, University College London; London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Comoglio+F%22">Comoglio F</searchLink>; enGene Statistics GmbH, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Edmondson+EF%22">Edmondson EF</searchLink>; Molecular Histopathology Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research; Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Chari+R%22">Chari R</searchLink>; Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research; Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22London+NR+Jr%22">London NR Jr</searchLink>; Sinonasal and Skull Base Tumor Section, Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD, USA.; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine; Baltimore, MD, USA.; Department of Neurosurgery, Johns Hopkins University School of Medicine; Baltimore, MD, USA.; Department of Oncology, Johns Hopkins University School of Medicine; Baltimore, MD, USA.
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