Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation (LLPS) and its reversal by selective, potent and orally-available PDE11A4 small molecule inhibitors both in vitro and in vivo.

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Title: Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation (LLPS) and its reversal by selective, potent and orally-available PDE11A4 small molecule inhibitors both in vitro and in vivo.
Authors: Amurrio E, Patel J, Danaher M, Elzaree L, Fisher JL, Greene H, Kargbo P, Kim P, Klimentova E, Lin S, Liu Y, Mehboob MY, Abdallah S, Temesgen Y, Ul Mahmood S, Rotella DP, Kelly MP
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 May 21. Date of Electronic Publication: 2025 May 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.05.20.654583