Combination therapy with levofloxacin and the probiotic Clostridium butyricum MIYAIRI 588 enhances immune checkpoint inhibitor efficacy.
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| Title: | Combination therapy with levofloxacin and the probiotic Clostridium butyricum MIYAIRI 588 enhances immune checkpoint inhibitor efficacy. |
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| Authors: | Tajima K; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan., Hosonuma M; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Division of Medical Oncology, Department of Medicine, Showa Medical University Graduate School of Medicine, Tokyo, Japan., Funayama E; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Pharmacy, Tokyo, Japan., Isobe J; Department of Hospital Pharmaceutics, School of Pharmacy, Showa Medical University, Tokyo, Japan., Baba Y; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Murayama M; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Department of Otorhinolaryngology-Head and Neck Surgery, Showa Medical University Graduate School of Medicine, Tokyo, Japan., Narikawa Y; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Department of Otorhinolaryngology-Head and Neck Surgery, Showa Medical University Graduate School of Medicine, Tokyo, Japan., Toyoda H; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Department of Orthopedic Surgery, Showa Medical University Graduate School of Medicine, Tokyo, Japan., Tsurui T; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Division of Medical Oncology, Department of Medicine, Showa Medical University Graduate School of Medicine, Tokyo, Japan., Maruyama Y; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Department of Otorhinolaryngology-Head and Neck Surgery, Showa Medical University Graduate School of Medicine, Tokyo, Japan., Sasaki A; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan., Amari Y; Division of Clinical Pharmacology, Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Department of Otolaryngology, Showa Medical University Fujigaoka Hospital, Yokohama, Japan., Yamazaki Y; Department of Toxicology, Showa Medical University Graduate School of Pharmacy, Tokyo, Japan., Nakashima R; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan., Shida M; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Sasaki A; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan., Sambe T; Division of Clinical Pharmacology, Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan., Wada S; Division of Medical Oncology, Department of Medicine, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Tsuji M; Pharmacological Research Center, Showa Medical University, Tokyo, Japan., Kiuchi Y; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan., Kobayashi S; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Kuramasu A; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan., Tsunoda T; Division of Medical Oncology, Department of Medicine, Showa Medical University Graduate School of Medicine, Tokyo, Japan., Mori M; Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan., Koyanagi K; Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan., Yoshimura K; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Division of Medical Oncology, Department of Medicine, Showa Medical University Graduate School of Medicine, Tokyo, Japan. |
| Source: | International journal of cancer [Int J Cancer] 2025 Sep 01; Vol. 157 (5), pp. 993-1005. Date of Electronic Publication: 2025 Jun 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40478177 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Combination therapy with levofloxacin and the probiotic Clostridium butyricum MIYAIRI 588 enhances immune checkpoint inhibitor efficacy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Tajima+K%22">Tajima K</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Hosonuma+M%22">Hosonuma M</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Division of Medical Oncology, Department of Medicine, Showa Medical University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Funayama+E%22">Funayama E</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Pharmacy, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Isobe+J%22">Isobe J</searchLink>; Department of Hospital Pharmaceutics, School of Pharmacy, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Baba+Y%22">Baba Y</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Murayama+M%22">Murayama M</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Department of Otorhinolaryngology-Head and Neck Surgery, Showa Medical University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Narikawa+Y%22">Narikawa Y</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Department of Otorhinolaryngology-Head and Neck Surgery, Showa Medical University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Toyoda+H%22">Toyoda H</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Department of Orthopedic Surgery, Showa Medical University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tsurui+T%22">Tsurui T</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Division of Medical Oncology, Department of Medicine, Showa Medical University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Maruyama+Y%22">Maruyama Y</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.; Department of Otorhinolaryngology-Head and Neck Surgery, Showa Medical University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sasaki+A%22">Sasaki A</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Amari+Y%22">Amari Y</searchLink>; Division of Clinical Pharmacology, Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Department of Otolaryngology, Showa Medical University Fujigaoka Hospital, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Yamazaki+Y%22">Yamazaki Y</searchLink>; Department of Toxicology, Showa Medical University Graduate School of Pharmacy, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Nakashima+R%22">Nakashima R</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Shida+M%22">Shida M</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sasaki+A%22">Sasaki A</searchLink>; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Sambe+T%22">Sambe T</searchLink>; Division of Clinical Pharmacology, Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Wada+S%22">Wada S</searchLink>; Division of Medical Oncology, Department of Medicine, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Department of Clinical Diagnostic Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tsuji+M%22">Tsuji M</searchLink>; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kiuchi+Y%22">Kiuchi Y</searchLink>; Department of Pharmacology, Showa Medical University Graduate School of Medicine, Tokyo, Japan.; Pharmacological Research Center, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+S%22">Kobayashi S</searchLink>; Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kuramasu+A%22">Kuramasu A</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tsunoda+T%22">Tsunoda T</searchLink>; Division of Medical Oncology, Department of Medicine, Showa Medical University Graduate School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Mori+M%22">Mori M</searchLink>; Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Koyanagi+K%22">Koyanagi K</searchLink>; Department of Gastroenterological Surgery, Tokai University School of Medicine, Kanagawa, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshimura+K%22">Yoshimura K</searchLink>; Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology and Therapeutics, Showa Medical University, Tokyo, Japan.; Division of Medical Oncology, Department of Medicine, Showa Medical University Graduate School of Medicine, Tokyo, Japan. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220042124%22">International journal of cancer</searchLink> [Int J Cancer] 2025 Sep 01; Vol. 157 (5), pp. 993-1005. <i>Date of Electronic Publication: </i>2025 Jun 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Liss%22">Wiley-Liss </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0042124 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-0215 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200207136%22">00207136 </searchLink><i>NLM ISO Abbreviation: </i>Int J Cancer <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/ijc.35472 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 993 Titles: – TitleFull: Combination therapy with levofloxacin and the probiotic Clostridium butyricum MIYAIRI 588 enhances immune checkpoint inhibitor efficacy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tajima K – PersonEntity: Name: NameFull: Hosonuma M – PersonEntity: Name: NameFull: Funayama E – PersonEntity: Name: NameFull: Isobe J – PersonEntity: Name: NameFull: Baba Y – PersonEntity: Name: NameFull: Murayama M – PersonEntity: Name: NameFull: Narikawa Y – PersonEntity: Name: NameFull: Toyoda H – PersonEntity: Name: NameFull: Tsurui T – PersonEntity: Name: NameFull: Maruyama Y – PersonEntity: Name: NameFull: Sasaki A – PersonEntity: Name: NameFull: Amari Y – PersonEntity: Name: NameFull: Yamazaki Y – PersonEntity: Name: NameFull: Nakashima R – PersonEntity: Name: NameFull: Shida M – PersonEntity: Name: NameFull: Sasaki A – PersonEntity: Name: NameFull: Sambe T – PersonEntity: Name: NameFull: Wada S – PersonEntity: Name: NameFull: Tsuji M – PersonEntity: Name: NameFull: Kiuchi Y – PersonEntity: Name: NameFull: Kobayashi S – PersonEntity: Name: NameFull: Kuramasu A – PersonEntity: Name: NameFull: Tsunoda T – PersonEntity: Name: NameFull: Mori M – PersonEntity: Name: NameFull: Koyanagi K – PersonEntity: Name: NameFull: Yoshimura K IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: 2025 Sep 01 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1097-0215 Numbering: – Type: volume Value: 157 – Type: issue Value: 5 Titles: – TitleFull: International journal of cancer Type: main |
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