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In vivo labeling reveals that degranulation is increased under supraphysiological TCR stimulation, but not infection, in CD8+ T cells from old mice.

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Title: In vivo labeling reveals that degranulation is increased under supraphysiological TCR stimulation, but not infection, in CD8+ T cells from old mice.
Authors: Dahlquist KJV; Biochemistry, Molecular Biology, and Biophysics Graduate Program, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Masonic Institute On the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Dehm EM; Masonic Institute On the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota, Minneapolis, MN, USA.; Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota Medical School, Minneapolis, MN, USA., Smith DM; Masonic Institute On the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA., Lucas ED; Center for Immunology, University of Minnesota, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Pierson M; Center for Immunology, University of Minnesota, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Hamilton SE; Center for Immunology, University of Minnesota, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Camell CD; Biochemistry, Molecular Biology, and Biophysics Graduate Program, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA. ccamell@umn.edu.; Masonic Institute On the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA. ccamell@umn.edu.; Center for Immunology, University of Minnesota, Minneapolis, MN, USA. ccamell@umn.edu.
Source: GeroScience [Geroscience] 2026 Feb; Vol. 48 (1), pp. 897-913. Date of Electronic Publication: 2025 Jun 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: In vivo labeling reveals that degranulation is increased under supraphysiological TCR stimulation, but not infection, in CD8<superscript>+</superscript> T cells from old mice.
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  Data: <searchLink fieldCode="AU" term="%22Dahlquist+KJV%22">Dahlquist KJV</searchLink>; Biochemistry, Molecular Biology, and Biophysics Graduate Program, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Masonic Institute On the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Dehm+EM%22">Dehm EM</searchLink>; Masonic Institute On the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.; Center for Immunology, University of Minnesota, Minneapolis, MN, USA.; Microbiology, Immunology, and Cancer Biology Graduate Program, University of Minnesota Medical School, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Smith+DM%22">Smith DM</searchLink>; Masonic Institute On the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Lucas+ED%22">Lucas ED</searchLink>; Center for Immunology, University of Minnesota, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pierson+M%22">Pierson M</searchLink>; Center for Immunology, University of Minnesota, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hamilton+SE%22">Hamilton SE</searchLink>; Center for Immunology, University of Minnesota, Minneapolis, MN, USA.; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Camell+CD%22">Camell CD</searchLink>; Biochemistry, Molecular Biology, and Biophysics Graduate Program, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA. ccamell@umn.edu.; Masonic Institute On the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA. ccamell@umn.edu.; Center for Immunology, University of Minnesota, Minneapolis, MN, USA. ccamell@umn.edu.
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  Data: <searchLink fieldCode="JN" term="%22101686284%22">GeroScience</searchLink> [Geroscience] 2026 Feb; Vol. 48 (1), pp. 897-913. <i>Date of Electronic Publication: </i>2025 Jun 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101686284 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2509-2723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225092723%22">25092723 </searchLink><i>NLM ISO Abbreviation: </i>Geroscience <i>Subsets: </i>MEDLINE
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              Text: 2026 Feb
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