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Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation.

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Title: Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation.
Authors: Scheithauer L; Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany., Ornago C; Department of Structure and Function of Proteins, Helmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, 38124, Braunschweig, Germany., Selmar J; Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany., Schütz C; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany., Bianchi G; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany., Kiefer A; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany., Haupenthal J; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany., Dellmann A; Institut für Pathologie, Städtisches Klinikum Braunschweig gGmbH, Celler Straße 38, 38114, Braunschweig, Germany., Huynh D; Herz, Thorax, Gefäßchirurgie, Städtisches Klinikum Braunschweig gGmbH, Salzdahlumer Straße 90, 38126. Braunschweig, Germany., Zhang R; Herz, Thorax, Gefäßchirurgie, Städtisches Klinikum Braunschweig gGmbH, Salzdahlumer Straße 90, 38126. Braunschweig, Germany., Blankenfeldt W; Department of Structure and Function of Proteins, Helmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, 38124, Braunschweig, Germany., Hirsch AH; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany., Steinert M; Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany. Electronic address: m.steinert@tu-bs.de.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Oct 15; Vol. 296, pp. 117832. Date of Electronic Publication: 2025 May 30.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
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  Data: Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation.
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  Data: <searchLink fieldCode="AU" term="%22Scheithauer+L%22">Scheithauer L</searchLink>; Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Ornago+C%22">Ornago C</searchLink>; Department of Structure and Function of Proteins, Helmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, 38124, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Selmar+J%22">Selmar J</searchLink>; Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Schütz+C%22">Schütz C</searchLink>; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Bianchi+G%22">Bianchi G</searchLink>; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Kiefer+A%22">Kiefer A</searchLink>; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Haupenthal+J%22">Haupenthal J</searchLink>; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Dellmann+A%22">Dellmann A</searchLink>; Institut für Pathologie, Städtisches Klinikum Braunschweig gGmbH, Celler Straße 38, 38114, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Huynh+D%22">Huynh D</searchLink>; Herz, Thorax, Gefäßchirurgie, Städtisches Klinikum Braunschweig gGmbH, Salzdahlumer Straße 90, 38126. Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Herz, Thorax, Gefäßchirurgie, Städtisches Klinikum Braunschweig gGmbH, Salzdahlumer Straße 90, 38126. Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Blankenfeldt+W%22">Blankenfeldt W</searchLink>; Department of Structure and Function of Proteins, Helmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, 38124, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Hirsch+AH%22">Hirsch AH</searchLink>; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Steinert+M%22">Steinert M</searchLink>; Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany. Electronic address: m.steinert@tu-bs.de.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2025 Oct 15; Vol. 296, pp. 117832. <i>Date of Electronic Publication: </i>2025 May 30.
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