Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation.
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| Title: | Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation. |
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| Authors: | Scheithauer L; Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany., Ornago C; Department of Structure and Function of Proteins, Helmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, 38124, Braunschweig, Germany., Selmar J; Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany., Schütz C; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany., Bianchi G; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany., Kiefer A; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany., Haupenthal J; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany., Dellmann A; Institut für Pathologie, Städtisches Klinikum Braunschweig gGmbH, Celler Straße 38, 38114, Braunschweig, Germany., Huynh D; Herz, Thorax, Gefäßchirurgie, Städtisches Klinikum Braunschweig gGmbH, Salzdahlumer Straße 90, 38126. Braunschweig, Germany., Zhang R; Herz, Thorax, Gefäßchirurgie, Städtisches Klinikum Braunschweig gGmbH, Salzdahlumer Straße 90, 38126. Braunschweig, Germany., Blankenfeldt W; Department of Structure and Function of Proteins, Helmholtz Centre for Infection Research (HZI), Inhoffenstraße 7, 38124, Braunschweig, Germany., Hirsch AH; Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Campus E8.1, 66123, Saarbrücken, Germany., Steinert M; Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany. Electronic address: m.steinert@tu-bs.de. |
| Source: | European journal of medicinal chemistry [Eur J Med Chem] 2025 Oct 15; Vol. 296, pp. 117832. Date of Electronic Publication: 2025 May 30. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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