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Structural and functional basis of mechanosensitive TMEM63 channelopathies.

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Title: Structural and functional basis of mechanosensitive TMEM63 channelopathies.
Authors: Zheng W; Departments of Otolaryngology & Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: wzheng86@wisc.edu., Lowry AJ; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA., Smith HE; Biophysics Program, The Ohio State University, Columbus, OH 43210, USA; Center for Mechanical Excitability, University of Chicago, Chicago, IL 60637, USA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA., Xie J; Department of Pathology, UMass Chan Medical School, Worcester, MA 01655, USA., Rawson S; Harvard Cryo-Electron Microscopy Center for Structural Biology, Harvard Medical School, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Wang C; Department of Pathology, UMass Chan Medical School, Worcester, MA 01655, USA., Ou J; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA., Sotomayor M; Center for Mechanical Excitability, University of Chicago, Chicago, IL 60637, USA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA., Fu TM; Department of Pathology, UMass Chan Medical School, Worcester, MA 01655, USA., Yang H; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA; Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA., Holt JR; Departments of Otolaryngology & Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: jeffrey.holt@childrens.harvard.edu.
Source: Neuron [Neuron] 2025 Aug 06; Vol. 113 (15), pp. 2474-2489.e5. Date of Electronic Publication: 2025 Jun 05.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zheng+W%22">Zheng W</searchLink>; Departments of Otolaryngology & Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: wzheng86@wisc.edu.<br /><searchLink fieldCode="AU" term="%22Lowry+AJ%22">Lowry AJ</searchLink>; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Smith+HE%22">Smith HE</searchLink>; Biophysics Program, The Ohio State University, Columbus, OH 43210, USA; Center for Mechanical Excitability, University of Chicago, Chicago, IL 60637, USA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; Department of Pathology, UMass Chan Medical School, Worcester, MA 01655, USA.<br /><searchLink fieldCode="AU" term="%22Rawson+S%22">Rawson S</searchLink>; Harvard Cryo-Electron Microscopy Center for Structural Biology, Harvard Medical School, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Department of Pathology, UMass Chan Medical School, Worcester, MA 01655, USA.<br /><searchLink fieldCode="AU" term="%22Ou+J%22">Ou J</searchLink>; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI 53705, USA.<br /><searchLink fieldCode="AU" term="%22Sotomayor+M%22">Sotomayor M</searchLink>; Center for Mechanical Excitability, University of Chicago, Chicago, IL 60637, USA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.<br /><searchLink fieldCode="AU" term="%22Fu+TM%22">Fu TM</searchLink>; Department of Pathology, UMass Chan Medical School, Worcester, MA 01655, USA.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA; Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Holt+JR%22">Holt JR</searchLink>; Departments of Otolaryngology & Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA. Electronic address: jeffrey.holt@childrens.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%228809320%22">Neuron</searchLink> [Neuron] 2025 Aug 06; Vol. 113 (15), pp. 2474-2489.e5. <i>Date of Electronic Publication: </i>2025 Jun 05.
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