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Sigma-1R-Pom121 axis preserves nuclear transport and integrity in poly-PR-induced C9orf72 ALS.

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Title: Sigma-1R-Pom121 axis preserves nuclear transport and integrity in poly-PR-induced C9orf72 ALS.
Authors: Lin CY; Neuroscience and Brain Disease Center, China Medical University, Taichung 404328, Taiwan; School of Medicine, College of Medicine, China Medical University, Taichung 404328, Taiwan., Wu HC; Neuroscience and Brain Disease Center, China Medical University, Taichung 404328, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 404328, Taiwan., Fu RH; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 404328, Taiwan; Ph.D. Program for Aging, China Medical University, Taichung 404328, Taiwan; Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan., Weng EF; Neuroscience and Brain Disease Center, China Medical University, Taichung 404328, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 404328, Taiwan., Hsieh WC; Neuroscience and Brain Disease Center, China Medical University, Taichung 404328, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 404328, Taiwan., Su TP; Cellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA., Wu HE; Cellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA., Wang SM; Neuroscience and Brain Disease Center, China Medical University, Taichung 404328, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 404328, Taiwan. Electronic address: wangs@mail.cmu.edu.tw.
Source: Neurobiology of disease [Neurobiol Dis] 2025 Aug; Vol. 212, pp. 106992. Date of Electronic Publication: 2025 Jun 05.
Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Sigma-1R-Pom121 axis preserves nuclear transport and integrity in poly-PR-induced C9orf72 ALS.
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  Data: <searchLink fieldCode="AU" term="%22Lin+CY%22">Lin CY</searchLink>; Neuroscience and Brain Disease Center, China Medical University, Taichung 404328, Taiwan; School of Medicine, College of Medicine, China Medical University, Taichung 404328, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+HC%22">Wu HC</searchLink>; Neuroscience and Brain Disease Center, China Medical University, Taichung 404328, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 404328, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fu+RH%22">Fu RH</searchLink>; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 404328, Taiwan; Ph.D. Program for Aging, China Medical University, Taichung 404328, Taiwan; Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan.<br /><searchLink fieldCode="AU" term="%22Weng+EF%22">Weng EF</searchLink>; Neuroscience and Brain Disease Center, China Medical University, Taichung 404328, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 404328, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+WC%22">Hsieh WC</searchLink>; Neuroscience and Brain Disease Center, China Medical University, Taichung 404328, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 404328, Taiwan.<br /><searchLink fieldCode="AU" term="%22Su+TP%22">Su TP</searchLink>; Cellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Wu+HE%22">Wu HE</searchLink>; Cellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Wang+SM%22">Wang SM</searchLink>; Neuroscience and Brain Disease Center, China Medical University, Taichung 404328, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 404328, Taiwan. Electronic address: wangs@mail.cmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%229500169%22">Neurobiology of disease</searchLink> [Neurobiol Dis] 2025 Aug; Vol. 212, pp. 106992. <i>Date of Electronic Publication: </i>2025 Jun 05.
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  Data: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9500169 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-953X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209699961%22">09699961 </searchLink><i>NLM ISO Abbreviation: </i>Neurobiol Dis <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.nbd.2025.106992
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        Text: English
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              Text: 2025 Aug
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              Y: 2025
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