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Modeling exposure-driven adverse events of EGFR TKIs in the treatment of patients with non-small cell lung cancer.

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Title: Modeling exposure-driven adverse events of EGFR TKIs in the treatment of patients with non-small cell lung cancer.
Authors: Yong L; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.; Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, China., Liu Y; Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing, 100191, China., Jian WZ; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China., Cai L; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China., Bao TY; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China., Liu C; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China., Gan EZ; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China., Wang TY; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China., Luo PY; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China., Cao BS; Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing, 100191, China. caobaoshan0711@aliyun.com., Liu W; Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, China. liuwei0023@bjmu.edu.cn., Zhou TY; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. tianyanzhou@bjmu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Nov; Vol. 46 (11), pp. 3087-3098. Date of Electronic Publication: 2025 Jun 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Yong+L%22">Yong L</searchLink>; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.; Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Jian+WZ%22">Jian WZ</searchLink>; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Cai+L%22">Cai L</searchLink>; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Bao+TY%22">Bao TY</searchLink>; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Gan+EZ%22">Gan EZ</searchLink>; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Wang+TY%22">Wang TY</searchLink>; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Luo+PY%22">Luo PY</searchLink>; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.<br /><searchLink fieldCode="AU" term="%22Cao+BS%22">Cao BS</searchLink>; Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing, 100191, China. caobaoshan0711@aliyun.com.<br /><searchLink fieldCode="AU" term="%22Liu+W%22">Liu W</searchLink>; Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, China. liuwei0023@bjmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhou+TY%22">Zhou TY</searchLink>; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. tianyanzhou@bjmu.edu.cn.
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