Phase 3 randomized trial of high-dose methotrexate for young children with high-risk embryonal brain tumors: A report from the Children's Oncology Group.

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Title: Phase 3 randomized trial of high-dose methotrexate for young children with high-risk embryonal brain tumors: A report from the Children's Oncology Group.
Authors: Mazewski C; Department of Pediatrics, Children's Healthcare of Atlanta - Egleston, Atlanta, GA., Leary SES; Department of Pediatrics, Seattle Children's, Seattle, WA., Kang G; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN., Li BK; Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario., Kellie S; Department of Oncology, Children's Hospital of Westmead Westmead, New South Wales., Hayes L; Department of Radiology, Children's Healthcare of Atlanta - Egleston, Atlanta, GA., Shaw D; Department of Radiology, Seattle Children's, Seattle, WA., Ho B; Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario., Reddy A; Department of Neurology, University of California, San Francisco, San Francisco, CA., Gossett J; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN., Burger PC; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD., Judkins AR; Department of Pathology, Children's Hospital Los Angeles, Los Angeles, CA., Aridgides P; Department of Radiation Oncology, State University of New York Upstate Medical University, Syracuse, NY., Geyer JR; Department of Pediatrics, Seattle Children's, Seattle, WA., Gajjar A; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN., Pollack IF; Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA., Fouladi M; Department of Pediatrics, Nationwide Children's Hospital Columbus, OH., Huang A; Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario.
Source: Neuro-oncology [Neuro Oncol] 2025 Oct 01; Vol. 27 (10), pp. 2726-2737.
Publication Type: Journal Article; Clinical Trial, Phase III; Randomized Controlled Trial
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase 3 randomized trial of high-dose methotrexate for young children with high-risk embryonal brain tumors: A report from the Children's Oncology Group.
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  Data: <searchLink fieldCode="AU" term="%22Mazewski+C%22">Mazewski C</searchLink>; Department of Pediatrics, Children's Healthcare of Atlanta - Egleston, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Leary+SES%22">Leary SES</searchLink>; Department of Pediatrics, Seattle Children's, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Kang+G%22">Kang G</searchLink>; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Li+BK%22">Li BK</searchLink>; Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario.<br /><searchLink fieldCode="AU" term="%22Kellie+S%22">Kellie S</searchLink>; Department of Oncology, Children's Hospital of Westmead Westmead, New South Wales.<br /><searchLink fieldCode="AU" term="%22Hayes+L%22">Hayes L</searchLink>; Department of Radiology, Children's Healthcare of Atlanta - Egleston, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Shaw+D%22">Shaw D</searchLink>; Department of Radiology, Seattle Children's, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Ho+B%22">Ho B</searchLink>; Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario.<br /><searchLink fieldCode="AU" term="%22Reddy+A%22">Reddy A</searchLink>; Department of Neurology, University of California, San Francisco, San Francisco, CA.<br /><searchLink fieldCode="AU" term="%22Gossett+J%22">Gossett J</searchLink>; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Burger+PC%22">Burger PC</searchLink>; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD.<br /><searchLink fieldCode="AU" term="%22Judkins+AR%22">Judkins AR</searchLink>; Department of Pathology, Children's Hospital Los Angeles, Los Angeles, CA.<br /><searchLink fieldCode="AU" term="%22Aridgides+P%22">Aridgides P</searchLink>; Department of Radiation Oncology, State University of New York Upstate Medical University, Syracuse, NY.<br /><searchLink fieldCode="AU" term="%22Geyer+JR%22">Geyer JR</searchLink>; Department of Pediatrics, Seattle Children's, Seattle, WA.<br /><searchLink fieldCode="AU" term="%22Gajjar+A%22">Gajjar A</searchLink>; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Pollack+IF%22">Pollack IF</searchLink>; Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA.<br /><searchLink fieldCode="AU" term="%22Fouladi+M%22">Fouladi M</searchLink>; Department of Pediatrics, Nationwide Children's Hospital Columbus, OH.<br /><searchLink fieldCode="AU" term="%22Huang+A%22">Huang A</searchLink>; Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario.
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  Data: <searchLink fieldCode="JN" term="%22100887420%22">Neuro-oncology</searchLink> [Neuro Oncol] 2025 Oct 01; Vol. 27 (10), pp. 2726-2737.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100887420 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1523-5866 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215228517%22">15228517 </searchLink><i>NLM ISO Abbreviation: </i>Neuro Oncol <i>Subsets: </i>MEDLINE
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        Value: 10.1093/neuonc/noaf132
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              Text: 2025 Oct 01
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