First-in-human evaluation of a no-alpha interleukin-2 mutein: safety and preliminary pharmacodynamic and clinical effect.
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| Title: | First-in-human evaluation of a no-alpha interleukin-2 mutein: safety and preliminary pharmacodynamic and clinical effect. |
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| Authors: | Caballero Aguirrechu I; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba., Mestre Fernández B; National Institute of Oncology and Radiobiology, Havana, Cuba., Soriano García JL; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba., Lim Alonso N; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba., Soto García A; National Institute of Oncology and Radiobiology, Havana, Cuba., Fleites Calvo V; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba., Mariño de la Puente D; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba., Vega Carvajal G; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba., Ávila Pérez JC; National Institute of Oncology and Radiobiology, Havana, Cuba., Mendoza Hernández I; National Coordinating Center of Clinical Trials, Havana, Cuba., García López E; National Coordinating Center of Clinical Trials, Havana, Cuba., Tarinas Reyes A; National Coordinating Center of Clinical Trials, Havana, Cuba., García-Pérez G; Center of Molecular Immunology, Havana, Cuba., Díaz Borges C; Center of Molecular Immunology, Havana, Cuba., Ledón Naranjo N; Center of Molecular Immunology, Havana, Cuba., Lozada Chang SL; Center of Molecular Immunology, Havana, Cuba., García Vega Y; Center of Molecular Immunology, Havana, Cuba., Alvárez Lobaina A; Center of Molecular Immunology, Havana, Cuba., Alvárez Cardona M; Center of Molecular Immunology, Havana, Cuba., Lorenzo-Luaces Alvárez P; Center of Molecular Immunology, Havana, Cuba., Crombet Ramos T; Center of Molecular Immunology, Havana, Cuba., Carmenate Portilla T; Center of Molecular Immunology, Havana, Cuba., León Monzón K; Center of Molecular Immunology, Havana, Cuba. |
| Source: | Frontiers in immunology [Front Immunol] 2025 May 23; Vol. 16, pp. 1589042. Date of Electronic Publication: 2025 May 23 (Print Publication: 2025). |
| Publication Type: | Journal Article; Clinical Trial, Phase I |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2025.1589042 |
