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First-in-human evaluation of a no-alpha interleukin-2 mutein: safety and preliminary pharmacodynamic and clinical effect.

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Title: First-in-human evaluation of a no-alpha interleukin-2 mutein: safety and preliminary pharmacodynamic and clinical effect.
Authors: Caballero Aguirrechu I; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba., Mestre Fernández B; National Institute of Oncology and Radiobiology, Havana, Cuba., Soriano García JL; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba., Lim Alonso N; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba., Soto García A; National Institute of Oncology and Radiobiology, Havana, Cuba., Fleites Calvo V; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba., Mariño de la Puente D; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba., Vega Carvajal G; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba., Ávila Pérez JC; National Institute of Oncology and Radiobiology, Havana, Cuba., Mendoza Hernández I; National Coordinating Center of Clinical Trials, Havana, Cuba., García López E; National Coordinating Center of Clinical Trials, Havana, Cuba., Tarinas Reyes A; National Coordinating Center of Clinical Trials, Havana, Cuba., García-Pérez G; Center of Molecular Immunology, Havana, Cuba., Díaz Borges C; Center of Molecular Immunology, Havana, Cuba., Ledón Naranjo N; Center of Molecular Immunology, Havana, Cuba., Lozada Chang SL; Center of Molecular Immunology, Havana, Cuba., García Vega Y; Center of Molecular Immunology, Havana, Cuba., Alvárez Lobaina A; Center of Molecular Immunology, Havana, Cuba., Alvárez Cardona M; Center of Molecular Immunology, Havana, Cuba., Lorenzo-Luaces Alvárez P; Center of Molecular Immunology, Havana, Cuba., Crombet Ramos T; Center of Molecular Immunology, Havana, Cuba., Carmenate Portilla T; Center of Molecular Immunology, Havana, Cuba., León Monzón K; Center of Molecular Immunology, Havana, Cuba.
Source: Frontiers in immunology [Front Immunol] 2025 May 23; Vol. 16, pp. 1589042. Date of Electronic Publication: 2025 May 23 (Print Publication: 2025).
Publication Type: Journal Article; Clinical Trial, Phase I
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: First-in-human evaluation of a no-alpha interleukin-2 mutein: safety and preliminary pharmacodynamic and clinical effect.
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  Data: <searchLink fieldCode="AU" term="%22Caballero+Aguirrechu+I%22">Caballero Aguirrechu I</searchLink>; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Mestre+Fernández+B%22">Mestre Fernández B</searchLink>; National Institute of Oncology and Radiobiology, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Soriano+García+JL%22">Soriano García JL</searchLink>; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Lim+Alonso+N%22">Lim Alonso N</searchLink>; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Soto+García+A%22">Soto García A</searchLink>; National Institute of Oncology and Radiobiology, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Fleites+Calvo+V%22">Fleites Calvo V</searchLink>; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Mariño+de+la+Puente+D%22">Mariño de la Puente D</searchLink>; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Vega+Carvajal+G%22">Vega Carvajal G</searchLink>; Hermanos Ameijeiras Hospital, Oncology Department, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Ávila+Pérez+JC%22">Ávila Pérez JC</searchLink>; National Institute of Oncology and Radiobiology, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Mendoza+Hernández+I%22">Mendoza Hernández I</searchLink>; National Coordinating Center of Clinical Trials, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22García+López+E%22">García López E</searchLink>; National Coordinating Center of Clinical Trials, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Tarinas+Reyes+A%22">Tarinas Reyes A</searchLink>; National Coordinating Center of Clinical Trials, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22García-Pérez+G%22">García-Pérez G</searchLink>; Center of Molecular Immunology, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Díaz+Borges+C%22">Díaz Borges C</searchLink>; Center of Molecular Immunology, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Ledón+Naranjo+N%22">Ledón Naranjo N</searchLink>; Center of Molecular Immunology, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Lozada+Chang+SL%22">Lozada Chang SL</searchLink>; Center of Molecular Immunology, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22García+Vega+Y%22">García Vega Y</searchLink>; Center of Molecular Immunology, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Alvárez+Lobaina+A%22">Alvárez Lobaina A</searchLink>; Center of Molecular Immunology, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Alvárez+Cardona+M%22">Alvárez Cardona M</searchLink>; Center of Molecular Immunology, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Lorenzo-Luaces+Alvárez+P%22">Lorenzo-Luaces Alvárez P</searchLink>; Center of Molecular Immunology, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Crombet+Ramos+T%22">Crombet Ramos T</searchLink>; Center of Molecular Immunology, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22Carmenate+Portilla+T%22">Carmenate Portilla T</searchLink>; Center of Molecular Immunology, Havana, Cuba.<br /><searchLink fieldCode="AU" term="%22León+Monzón+K%22">León Monzón K</searchLink>; Center of Molecular Immunology, Havana, Cuba.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2025 May 23; Vol. 16, pp. 1589042. <i>Date of Electronic Publication: </i>2025 May 23 (<i>Print Publication: </i>2025).
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  Data: Journal Article; Clinical Trial, Phase I
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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