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International Myeloma Society/International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma.

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Title: International Myeloma Society/International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma.
Authors: Avet-Loiseau H; Unité de Genomique du Myélome, Institut National de la Santé et de la Recherche Médicale, University Cancer Center of Toulouse, Toulouse, France., Davies FE; Perlmutter Cancer Center, NYU Langone Health, New York, NY., Samur MK; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA., Corre J; Unité de Genomique du Myélome, Institut National de la Santé et de la Recherche Médicale, University Cancer Center of Toulouse, Toulouse, France., D'Agostino M; Division of Hematology, AOU Città della Salute e della Scienza di Torino, Torino, Italy.; University of Torino and Department of Molecular Biotechnology and Health Sciences, Torino, Italy., Kaiser MF; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.; Department of Haematology, The Royal Marsden Hospital, London, United Kingdom., Raab MS; Department of Medicine V, Heidelberg Myeloma Center, University Hospital and Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany., Weinhold N; Department of Medicine V, Heidelberg Myeloma Center, University Hospital and Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany., Gutierrez NC; Departamento de Hematología, Hospital Universitario de Salamanca, (HUSA/IBSAL), Centro de Investigación del Cáncer-IBMCC (CSIC/USAL), CIBERONC, Salamanca, Spain., Paiva B; Cancer Center Clínica Universidad de Navarra (CCUN), Centro de Investigación Médica Aplicada (CIMA LAB Diagnostics), IDISNA, CIBERONC, Pamplona, Spain., Neri P; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Canada., Weisel K; Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Maura F; Division of Myeloma, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL., Walker BA; Division of Hematology and Oncology, School of Medicine, Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, IN., Bustoros M; Division of Hematology and Medical Oncology, Joan and Sanford I. Weill Department of Medicine, Sandra & Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY., Stewart AK; Division of Hematology-Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada., Usmani SZ; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Hillengass J; Department of Medicine-Myeloma, Roswell Park Comprehensive Cancer Center, Buffalo, NY., Chng WJ; Department of Medical Oncology, National University Cancer Institute, and Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Keats JJ; Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ., Martinez-Lopez J; Hospital 12 de Octubre, i+12, School of Medicine Universidad Complutense, CNIO, Madrid, Spain., Sperling AS; Dana-Farber Cancer Institute, Boston, MA., Touzeau C; Hematology Department, University Hospital Hôtel-Dieu, Nantes, France., Zhan F; Department of Internal Medicine, Myeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR., Raje NS; Department of Hematology/Oncology, Center for Multiple Myeloma, Harvard Medical School, Massachusetts General Hospital, Boston, MA., Cavo M; Dipartimento di Scienze Mediche e Chirurgiche, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli', Università di Bologna, Bologna, Italy., Bolli N; Department of Oncology and Onco-Hematology, University of Milan and Hematology Section Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Ghobrial IM; Department of Medical Oncology, Center for Early Detection and Interception of Blood Cancers, Dana-Farber Cancer Institute, Boston, MA., Dhodapkar MV; Emory University School of Medicine, Atlanta, GA., Jagannath S; Icahn School of Medicine at Mount Sinai, New York, NY., Spencer A; Department of Haematology, The Alfred Hospital and Monash University, Melbourne, Australia., Parekh S; Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY., Bahlis NJ; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Canada., Lonial S; Winship Cancer Institute, Emory University, Atlanta, GA., Sonneveld P; Department of Hematology, EMN/Erasmus MC Cancer Institute, Rotterdam, the Netherlands., Bergsagel L; Division of Hematology, Mayo Clinic, Phoenix, AZ., Orlowski RZ; Departments of Lymphoma/Myeloma and Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX., Morgan G; Perlmutter Cancer Center, NYU Langone Health, New York, NY., Mateos MV; Departamento de Hematología, Hospital Universitario de Salamanca, (HUSA/IBSAL), Centro de Investigación del Cáncer-IBMCC (CSIC/USAL), CIBERONC, Salamanca, Spain., Rajkumar SV; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN., San Miguel JF; Cancer Center Clínica Universidad de Navarra (CCUN), CIMA, CIBERONC, IDISNA, Pamplona, Spain., Anderson KC; Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA., Moreau P; Hematology Department, University Hospital Hôtel-Dieu, Nantes, France., Kumar S; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN., Prósper F; Hematology and Cell Therapy and Program of Hematology-Oncology CIMA, Clinica Universidad de Navarra, IdISNA, CIBERONC, Pamplona, Spain., Munshi NC; Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA.
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2025 Aug 20; Vol. 43 (24), pp. 2739-2751. Date of Electronic Publication: 2025 Jun 09.
Publication Type: Journal Article; Consensus Statement; Practice Guideline; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Avet-Loiseau+H%22">Avet-Loiseau H</searchLink>; Unité de Genomique du Myélome, Institut National de la Santé et de la Recherche Médicale, University Cancer Center of Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Davies+FE%22">Davies FE</searchLink>; Perlmutter Cancer Center, NYU Langone Health, New York, NY.<br /><searchLink fieldCode="AU" term="%22Samur+MK%22">Samur MK</searchLink>; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Corre+J%22">Corre J</searchLink>; Unité de Genomique du Myélome, Institut National de la Santé et de la Recherche Médicale, University Cancer Center of Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22D'Agostino+M%22">D'Agostino M</searchLink>; Division of Hematology, AOU Città della Salute e della Scienza di Torino, Torino, Italy.; University of Torino and Department of Molecular Biotechnology and Health Sciences, Torino, Italy.<br /><searchLink fieldCode="AU" term="%22Kaiser+MF%22">Kaiser MF</searchLink>; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.; Department of Haematology, The Royal Marsden Hospital, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Raab+MS%22">Raab MS</searchLink>; Department of Medicine V, Heidelberg Myeloma Center, University Hospital and Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Weinhold+N%22">Weinhold N</searchLink>; Department of Medicine V, Heidelberg Myeloma Center, University Hospital and Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Gutierrez+NC%22">Gutierrez NC</searchLink>; Departamento de Hematología, Hospital Universitario de Salamanca, (HUSA/IBSAL), Centro de Investigación del Cáncer-IBMCC (CSIC/USAL), CIBERONC, Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Paiva+B%22">Paiva B</searchLink>; Cancer Center Clínica Universidad de Navarra (CCUN), Centro de Investigación Médica Aplicada (CIMA LAB Diagnostics), IDISNA, CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Neri+P%22">Neri P</searchLink>; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Canada.<br /><searchLink fieldCode="AU" term="%22Weisel+K%22">Weisel K</searchLink>; Department of Oncology, Hematology and Bone Marrow Transplantation with Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Maura+F%22">Maura F</searchLink>; Division of Myeloma, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL.<br /><searchLink fieldCode="AU" term="%22Walker+BA%22">Walker BA</searchLink>; Division of Hematology and Oncology, School of Medicine, Melvin and Bren Simon Comprehensive Cancer Center, Indiana University, Indianapolis, IN.<br /><searchLink fieldCode="AU" term="%22Bustoros+M%22">Bustoros M</searchLink>; Division of Hematology and Medical Oncology, Joan and Sanford I. Weill Department of Medicine, Sandra & Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY.<br /><searchLink fieldCode="AU" term="%22Stewart+AK%22">Stewart AK</searchLink>; Division of Hematology-Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Usmani+SZ%22">Usmani SZ</searchLink>; Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.<br /><searchLink fieldCode="AU" term="%22Hillengass+J%22">Hillengass J</searchLink>; Department of Medicine-Myeloma, Roswell Park Comprehensive Cancer Center, Buffalo, NY.<br /><searchLink fieldCode="AU" term="%22Chng+WJ%22">Chng WJ</searchLink>; Department of Medical Oncology, National University Cancer Institute, and Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Keats+JJ%22">Keats JJ</searchLink>; Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ.<br /><searchLink fieldCode="AU" term="%22Martinez-Lopez+J%22">Martinez-Lopez J</searchLink>; Hospital 12 de Octubre, i+12, School of Medicine Universidad Complutense, CNIO, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Sperling+AS%22">Sperling AS</searchLink>; Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Touzeau+C%22">Touzeau C</searchLink>; Hematology Department, University Hospital Hôtel-Dieu, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Zhan+F%22">Zhan F</searchLink>; Department of Internal Medicine, Myeloma Center, Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR.<br /><searchLink fieldCode="AU" term="%22Raje+NS%22">Raje NS</searchLink>; Department of Hematology/Oncology, Center for Multiple Myeloma, Harvard Medical School, Massachusetts General Hospital, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Cavo+M%22">Cavo M</searchLink>; Dipartimento di Scienze Mediche e Chirurgiche, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Istituto di Ematologia 'Seràgnoli', Università di Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Bolli+N%22">Bolli N</searchLink>; Department of Oncology and Onco-Hematology, University of Milan and Hematology Section Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ghobrial+IM%22">Ghobrial IM</searchLink>; Department of Medical Oncology, Center for Early Detection and Interception of Blood Cancers, Dana-Farber Cancer Institute, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Dhodapkar+MV%22">Dhodapkar MV</searchLink>; Emory University School of Medicine, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Jagannath+S%22">Jagannath S</searchLink>; Icahn School of Medicine at Mount Sinai, New York, NY.<br /><searchLink fieldCode="AU" term="%22Spencer+A%22">Spencer A</searchLink>; Department of Haematology, The Alfred Hospital and Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Parekh+S%22">Parekh S</searchLink>; Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY.<br /><searchLink fieldCode="AU" term="%22Bahlis+NJ%22">Bahlis NJ</searchLink>; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, Canada.<br /><searchLink fieldCode="AU" term="%22Lonial+S%22">Lonial S</searchLink>; Winship Cancer Institute, Emory University, Atlanta, GA.<br /><searchLink fieldCode="AU" term="%22Sonneveld+P%22">Sonneveld P</searchLink>; Department of Hematology, EMN/Erasmus MC Cancer Institute, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bergsagel+L%22">Bergsagel L</searchLink>; Division of Hematology, Mayo Clinic, Phoenix, AZ.<br /><searchLink fieldCode="AU" term="%22Orlowski+RZ%22">Orlowski RZ</searchLink>; Departments of Lymphoma/Myeloma and Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX.<br /><searchLink fieldCode="AU" term="%22Morgan+G%22">Morgan G</searchLink>; Perlmutter Cancer Center, NYU Langone Health, New York, NY.<br /><searchLink fieldCode="AU" term="%22Mateos+MV%22">Mateos MV</searchLink>; Departamento de Hematología, Hospital Universitario de Salamanca, (HUSA/IBSAL), Centro de Investigación del Cáncer-IBMCC (CSIC/USAL), CIBERONC, Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Rajkumar+SV%22">Rajkumar SV</searchLink>; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22San+Miguel+JF%22">San Miguel JF</searchLink>; Cancer Center Clínica Universidad de Navarra (CCUN), CIMA, CIBERONC, IDISNA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Anderson+KC%22">Anderson KC</searchLink>; Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA.<br /><searchLink fieldCode="AU" term="%22Moreau+P%22">Moreau P</searchLink>; Hematology Department, University Hospital Hôtel-Dieu, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Kumar+S%22">Kumar S</searchLink>; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN.<br /><searchLink fieldCode="AU" term="%22Prósper+F%22">Prósper F</searchLink>; Hematology and Cell Therapy and Program of Hematology-Oncology CIMA, Clinica Universidad de Navarra, IdISNA, CIBERONC, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Munshi+NC%22">Munshi NC</searchLink>; Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA.
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