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Inhibiting microtubule polymerization with EAPB02303, a prodrug activated by catechol-O-methyl transferase, enhances paclitaxel effect in pancreatic cancer models.

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Title: Inhibiting microtubule polymerization with EAPB02303, a prodrug activated by catechol-O-methyl transferase, enhances paclitaxel effect in pancreatic cancer models.
Authors: Bigot K; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France., Patinote C; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, (CNRS, ENSCM, Université de Montpellier), Montpellier, France., Garambois V; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France., Chouchou A; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, (CNRS, ENSCM, Université de Montpellier), Montpellier, France., Gayraud-Paniagua S; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, (CNRS, ENSCM, Université de Montpellier), Montpellier, France., Vie N; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France., Maggipinto Y; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France., Smyej E; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France., Robin M; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France., Machu M; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France., Bruciamacchie M; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France., Colombo PE; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France., Bousquet C; Université Toulouse III-Paul Sabatier - Centre de Recherche en Cancérologie de Toulouse (CRCT) - UMR1037 Inserm- UMR, 5071 CNRS, Toulouse, France., Mathonnet M; INSERM UMLR-1308, University of Limoges, Limoges, France., Levy-Augé E; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, (CNRS, ENSCM, Université de Montpellier), Montpellier, France., Tosi D; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France., Bonnet PA; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, (CNRS, ENSCM, Université de Montpellier), Montpellier, France., Gongora C; IRCM, Université de Montpellier, Inserm, ICM, CNRS, Montpellier, France., Deleuze-Masquéfa C; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, (CNRS, ENSCM, Université de Montpellier), Montpellier, France. carine.masquefa@umontpellier.fr., Larbouret C; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France. Christel.larbouret@inserm.fr.
Source: Cell death & disease [Cell Death Dis] 2025 Jun 09; Vol. 16 (1), pp. 441. Date of Electronic Publication: 2025 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Inhibiting microtubule polymerization with EAPB02303, a prodrug activated by catechol-O-methyl transferase, enhances paclitaxel effect in pancreatic cancer models.
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  Data: <searchLink fieldCode="AU" term="%22Bigot+K%22">Bigot K</searchLink>; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Patinote+C%22">Patinote C</searchLink>; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, (CNRS, ENSCM, Université de Montpellier), Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Garambois+V%22">Garambois V</searchLink>; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Chouchou+A%22">Chouchou A</searchLink>; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, (CNRS, ENSCM, Université de Montpellier), Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Gayraud-Paniagua+S%22">Gayraud-Paniagua S</searchLink>; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, (CNRS, ENSCM, Université de Montpellier), Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Vie+N%22">Vie N</searchLink>; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Maggipinto+Y%22">Maggipinto Y</searchLink>; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Smyej+E%22">Smyej E</searchLink>; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Robin+M%22">Robin M</searchLink>; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Machu+M%22">Machu M</searchLink>; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Bruciamacchie+M%22">Bruciamacchie M</searchLink>; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Colombo+PE%22">Colombo PE</searchLink>; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Bousquet+C%22">Bousquet C</searchLink>; Université Toulouse III-Paul Sabatier - Centre de Recherche en Cancérologie de Toulouse (CRCT) - UMR1037 Inserm- UMR, 5071 CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Mathonnet+M%22">Mathonnet M</searchLink>; INSERM UMLR-1308, University of Limoges, Limoges, France.<br /><searchLink fieldCode="AU" term="%22Levy-Augé+E%22">Levy-Augé E</searchLink>; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, (CNRS, ENSCM, Université de Montpellier), Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Tosi+D%22">Tosi D</searchLink>; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Bonnet+PA%22">Bonnet PA</searchLink>; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, (CNRS, ENSCM, Université de Montpellier), Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Gongora+C%22">Gongora C</searchLink>; IRCM, Université de Montpellier, Inserm, ICM, CNRS, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Deleuze-Masquéfa+C%22">Deleuze-Masquéfa C</searchLink>; Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, (CNRS, ENSCM, Université de Montpellier), Montpellier, France. carine.masquefa@umontpellier.fr.<br /><searchLink fieldCode="AU" term="%22Larbouret+C%22">Larbouret C</searchLink>; IRCM, Université de Montpellier, Inserm, ICM, Montpellier, France. Christel.larbouret@inserm.fr.
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