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Pore formation by the CDTb component of the Clostridioides difficile binary toxin is Ca2+-dependent.

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Title: Pore formation by the CDTb component of the Clostridioides difficile binary toxin is Ca2+-dependent.
Authors: Abeyawardhane DL; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA., Sevdalis SE; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA., Adipietro KA; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA., Godoy-Ruiz R; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA., Varney KM; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA., Nawaz IF; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA., Spittel AX; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA., Hunter D; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA., Rustandi RR; Merck & Co. Inc., Kenilworth, NJ, USA., Silin VI; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; National Institute of Standards and Technology, Gaithersburg, MD, USA., des Georges A; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, NY, USA.; Department of Chemistry and Biochemistry, City College of New York, New York, NY, USA.; PhD Programs in Biochemistry and Chemistry, Graduate Center, City University of New York, New York, NY, USA., Cook ME; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA., Pozharski E; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA. epozharskiy@som.umaryland.edu.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA. epozharskiy@som.umaryland.edu.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA. epozharskiy@som.umaryland.edu., Weber DJ; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA. dweber@som.umaryland.edu.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA. dweber@som.umaryland.edu.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA. dweber@som.umaryland.edu.
Source: Communications biology [Commun Biol] 2025 Jun 09; Vol. 8 (1), pp. 901. Date of Electronic Publication: 2025 Jun 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
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  Data: Pore formation by the CDTb component of the Clostridioides difficile binary toxin is Ca<superscript>2+</superscript>-dependent.
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  Data: <searchLink fieldCode="AU" term="%22Abeyawardhane+DL%22">Abeyawardhane DL</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sevdalis+SE%22">Sevdalis SE</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Adipietro+KA%22">Adipietro KA</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Godoy-Ruiz+R%22">Godoy-Ruiz R</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Varney+KM%22">Varney KM</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Nawaz+IF%22">Nawaz IF</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Spittel+AX%22">Spittel AX</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hunter+D%22">Hunter D</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Rustandi+RR%22">Rustandi RR</searchLink>; Merck & Co. Inc., Kenilworth, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Silin+VI%22">Silin VI</searchLink>; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA.; National Institute of Standards and Technology, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22des+Georges+A%22">des Georges A</searchLink>; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, NY, USA.; Department of Chemistry and Biochemistry, City College of New York, New York, NY, USA.; PhD Programs in Biochemistry and Chemistry, Graduate Center, City University of New York, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cook+ME%22">Cook ME</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Pozharski+E%22">Pozharski E</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA. epozharskiy@som.umaryland.edu.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA. epozharskiy@som.umaryland.edu.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA. epozharskiy@som.umaryland.edu.<br /><searchLink fieldCode="AU" term="%22Weber+DJ%22">Weber DJ</searchLink>; Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, USA. dweber@som.umaryland.edu.; Institute for Bioscience and Biotechnology Research (IBBR), University of Maryland, Rockville, MD, USA. dweber@som.umaryland.edu.; The Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD, USA. dweber@som.umaryland.edu.
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