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OSBPL11 is an African-specific locus associated with 25-hydroxyvitamin D concentrations and cardiometabolic health.

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Title: OSBPL11 is an African-specific locus associated with 25-hydroxyvitamin D concentrations and cardiometabolic health.
Authors: Mogire RM; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya.; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, Maryland 20891-5635, USA., Muriuki JM; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya., Bayimenye RF; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117 USA., Mentzer AJ; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Chong A; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, UK., Gouveia MH; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, Maryland 20891-5635, USA., Bentley AR; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, Maryland 20891-5635, USA., Band G; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, UK., King'ori P; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya., Mitchell R; Medical Research Council (MRC) Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Webb EL; MRC International Statistics and Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK., Sengupta D; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa., Ekunwe L; Department of Medicine, University of MS Medical Center (UMMC), Jackson, MS 39213, USA., Ndungu FM; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya., Morovat A; Department of Clinical Biochemistry, Oxford University Hospitals, Oxford, UK., Macharia AW; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya., Cutland CL; African Leadership in Vaccinology Expertise (Alive), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Hemani G; Medical Research Council (MRC) Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Sirima SB; Centre de Recherche Action en Sante (GRAS), 06 BP 10248, Ouagadougou 06, Burkina Faso., Ramsay M; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa.; Division of Human Genetics, National Health Laboratory Service and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Figueiredo CA; Departamento de Ciências da Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, 40110-100, Salvador, Bahia, Brazil., Prentice AM; MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia., Madhi SA; South African Medical Research Council: Vaccines and Infectious Diseases Analytical Research Unit (VIDA), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Sandhu MS; Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, UK., Bejon P; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Smith GD; Medical Research Council (MRC) Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Elliott AM; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda., Williams TN; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya.; Institute of Global Health Innovation, Department of Surgery and Cancer, Imperial College, London, UK., Rotimi C; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, Maryland 20891-5635, USA., Bourne CR; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States., Burgett A; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117 USA., Adeyemo A; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, Maryland 20891-5635, USA., Atkinson SH; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, Maryland 20891-5635, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 May 31. Date of Electronic Publication: 2025 May 31.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: OSBPL11 is an African-specific locus associated with 25-hydroxyvitamin D concentrations and cardiometabolic health.
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  Data: <searchLink fieldCode="AU" term="%22Mogire+RM%22">Mogire RM</searchLink>; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya.; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, Maryland 20891-5635, USA.<br /><searchLink fieldCode="AU" term="%22Muriuki+JM%22">Muriuki JM</searchLink>; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Bayimenye+RF%22">Bayimenye RF</searchLink>; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117 USA.<br /><searchLink fieldCode="AU" term="%22Mentzer+AJ%22">Mentzer AJ</searchLink>; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, UK.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Chong+A%22">Chong A</searchLink>; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Gouveia+MH%22">Gouveia MH</searchLink>; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, Maryland 20891-5635, USA.<br /><searchLink fieldCode="AU" term="%22Bentley+AR%22">Bentley AR</searchLink>; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, Maryland 20891-5635, USA.<br /><searchLink fieldCode="AU" term="%22Band+G%22">Band G</searchLink>; Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, UK.<br /><searchLink fieldCode="AU" term="%22King'ori+P%22">King'ori P</searchLink>; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Mitchell+R%22">Mitchell R</searchLink>; Medical Research Council (MRC) Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Webb+EL%22">Webb EL</searchLink>; MRC International Statistics and Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Sengupta+D%22">Sengupta D</searchLink>; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa.<br /><searchLink fieldCode="AU" term="%22Ekunwe+L%22">Ekunwe L</searchLink>; Department of Medicine, University of MS Medical Center (UMMC), Jackson, MS 39213, USA.<br /><searchLink fieldCode="AU" term="%22Ndungu+FM%22">Ndungu FM</searchLink>; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Morovat+A%22">Morovat A</searchLink>; Department of Clinical Biochemistry, Oxford University Hospitals, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Macharia+AW%22">Macharia AW</searchLink>; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya.<br /><searchLink fieldCode="AU" term="%22Cutland+CL%22">Cutland CL</searchLink>; African Leadership in Vaccinology Expertise (Alive), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Hemani+G%22">Hemani G</searchLink>; Medical Research Council (MRC) Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Sirima+SB%22">Sirima SB</searchLink>; Centre de Recherche Action en Sante (GRAS), 06 BP 10248, Ouagadougou 06, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Ramsay+M%22">Ramsay M</searchLink>; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa.; Division of Human Genetics, National Health Laboratory Service and School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Figueiredo+CA%22">Figueiredo CA</searchLink>; Departamento de Ciências da Biointeração, Instituto de Ciências da Saúde, Universidade Federal da Bahia, 40110-100, Salvador, Bahia, Brazil.<br /><searchLink fieldCode="AU" term="%22Prentice+AM%22">Prentice AM</searchLink>; MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia.<br /><searchLink fieldCode="AU" term="%22Madhi+SA%22">Madhi SA</searchLink>; South African Medical Research Council: Vaccines and Infectious Diseases Analytical Research Unit (VIDA), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Raffield+LM%22">Raffield LM</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Sandhu+MS%22">Sandhu MS</searchLink>; Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Bejon+P%22">Bejon P</searchLink>; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Smith+GD%22">Smith GD</searchLink>; Medical Research Council (MRC) Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.<br /><searchLink fieldCode="AU" term="%22Elliott+AM%22">Elliott AM</searchLink>; Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.<br /><searchLink fieldCode="AU" term="%22Williams+TN%22">Williams TN</searchLink>; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya.; Institute of Global Health Innovation, Department of Surgery and Cancer, Imperial College, London, UK.<br /><searchLink fieldCode="AU" term="%22Rotimi+C%22">Rotimi C</searchLink>; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, Maryland 20891-5635, USA.<br /><searchLink fieldCode="AU" term="%22Bourne+CR%22">Bourne CR</searchLink>; Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.<br /><searchLink fieldCode="AU" term="%22Burgett+A%22">Burgett A</searchLink>; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73117 USA.<br /><searchLink fieldCode="AU" term="%22Adeyemo+A%22">Adeyemo A</searchLink>; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, Maryland 20891-5635, USA.<br /><searchLink fieldCode="AU" term="%22Atkinson+SH%22">Atkinson SH</searchLink>; Centre for Geographic Medicine Research-Coast, KEMRI-Wellcome Trust Research Programme, Kenya Medical Research Institute (KEMRI), Kilifi, Kenya.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, MSC 5635, Bethesda, Maryland 20891-5635, USA.
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