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Augmented Enteral Protein During Critical Illness: The TARGET Protein Randomized Clinical Trial.

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Title: Augmented Enteral Protein During Critical Illness: The TARGET Protein Randomized Clinical Trial.
Authors: Summers MJ; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia., Chapple LS; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Centre for Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia., Karahalios A; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.; Methods and Implementation Support for Clinical and Health research (MISCH) Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia., Bellomo R; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.; Intensive Care Unit, Austin Health, Heidelberg, Victoria, Australia.; Department of Critical Care, The University of Melbourne, Melbourne, Australia., Chapman MJ; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Centre for Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia., Ferrie S; Department of Nutrition & Dietetics, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, Australia., Finnis ME; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.; Department of Critical Care, The University of Melbourne, Melbourne, Australia., French C; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Sunshine Hospital, Melbourne, Victoria, Australia., Hurford S; Medical Research Institute of New Zealand, Wellington, New Zealand., Kakho N; Intensive Care Unit, University Hospital Geelong, Geelong, Victoria, Australia., Maiden MJ; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, University Hospital Geelong, Geelong, Victoria, Australia.; Intensive Care Unit, Royal Melbourne Hospital, Parkville, Victoria, Australia., O'Connor SN; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia., Peake SL; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.; Department of Intensive Care Medicine, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia., Presneill JJ; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Royal Melbourne Hospital, Parkville, Victoria, Australia., Ridley EJ; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.; Dietetics and Nutrition, Alfred Hospital, Melbourne, Victoria, Australia., Tran-Duy A; Methods and Implementation Support for Clinical and Health research (MISCH) Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.; Centre for Health Policy, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Williams PJ; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.; Department of Intensive Care Medicine, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia., Young PJ; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Sunshine Hospital, Melbourne, Victoria, Australia.; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand., Zaloumis S; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.; Methods and Implementation Support for Clinical and Health research (MISCH) Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia., Deane AM; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Corporate Authors: TARGET Protein Investigators and for the Australian and New Zealand Intensive Care Society Clinical Trials Group
Source: JAMA [JAMA] 2025 Jul 22; Vol. 334 (4), pp. 319-328.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Augmented Enteral Protein During Critical Illness: The TARGET Protein Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Summers+MJ%22">Summers MJ</searchLink>; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Chapple+LS%22">Chapple LS</searchLink>; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Centre for Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Karahalios+A%22">Karahalios A</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.; Methods and Implementation Support for Clinical and Health research (MISCH) Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Bellomo+R%22">Bellomo R</searchLink>; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.; Intensive Care Unit, Austin Health, Heidelberg, Victoria, Australia.; Department of Critical Care, The University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Chapman+MJ%22">Chapman MJ</searchLink>; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Centre for Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ferrie+S%22">Ferrie S</searchLink>; Department of Nutrition & Dietetics, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.; Faculty of Medicine and Health, University of Sydney, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Finnis+ME%22">Finnis ME</searchLink>; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.; Department of Critical Care, The University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22French+C%22">French C</searchLink>; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Sunshine Hospital, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Hurford+S%22">Hurford S</searchLink>; Medical Research Institute of New Zealand, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22Kakho+N%22">Kakho N</searchLink>; Intensive Care Unit, University Hospital Geelong, Geelong, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Maiden+MJ%22">Maiden MJ</searchLink>; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, University Hospital Geelong, Geelong, Victoria, Australia.; Intensive Care Unit, Royal Melbourne Hospital, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22O'Connor+SN%22">O'Connor SN</searchLink>; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Intensive Care Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Peake+SL%22">Peake SL</searchLink>; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.; Department of Intensive Care Medicine, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Presneill+JJ%22">Presneill JJ</searchLink>; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Royal Melbourne Hospital, Parkville, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ridley+EJ%22">Ridley EJ</searchLink>; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.; Dietetics and Nutrition, Alfred Hospital, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Tran-Duy+A%22">Tran-Duy A</searchLink>; Methods and Implementation Support for Clinical and Health research (MISCH) Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.; Centre for Health Policy, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Williams+PJ%22">Williams PJ</searchLink>; Discipline of Acute Care Medicine, The University of Adelaide, Adelaide, South Australia, Australia.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia.; Department of Intensive Care Medicine, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.<br /><searchLink fieldCode="AU" term="%22Young+PJ%22">Young PJ</searchLink>; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Sunshine Hospital, Melbourne, Victoria, Australia.; Intensive Care Unit, Wellington Hospital, Wellington, New Zealand.<br /><searchLink fieldCode="AU" term="%22Zaloumis+S%22">Zaloumis S</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.; Methods and Implementation Support for Clinical and Health research (MISCH) Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Deane+AM%22">Deane AM</searchLink>; Department of Critical Care, The University of Melbourne, Melbourne, Australia.; Intensive Care Unit, Royal Melbourne Hospital, Parkville, Victoria, Australia.
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  Data: <searchLink fieldCode="JN" term="%227501160%22">JAMA</searchLink> [JAMA] 2025 Jul 22; Vol. 334 (4), pp. 319-328.
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