Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers.
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| Title: | Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers. |
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| Authors: | Rao SM; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States., Chorba AL; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States., Helppi MJ; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States., Tuladhar A; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States., Penko AL; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States., Holley S; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States., Nehls B; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States., Paulino S; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States., Streicher MC; Concussion Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States., Zhu A; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States., Bruening K; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States., Durgerian S; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States., Koenig K; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States., Lowe M; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States., Shin W; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States., Jones SE; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States., Galioto R; Mellen Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States., Pillai JA; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States., Bekris LM; Lerner Research Institute, Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, United States., Leverenz JB; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States., Rosenfeldt AB; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States., Singh T; Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States., Beck GJ; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States., Smith JC; Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD, United States., Alberts J; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.; Concussion Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States. |
| Source: | Frontiers in aging neuroscience [Front Aging Neurosci] 2025 May 27; Vol. 17, pp. 1584115. Date of Electronic Publication: 2025 May 27 (Print Publication: 2025). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101525824 Publication Model: eCollection Cited Medium: Print ISSN: 1663-4365 (Print) Linking ISSN: 16634365 NLM ISO Abbreviation: Front Aging Neurosci Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40496973 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Rao+SM%22">Rao SM</searchLink>; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Chorba+AL%22">Chorba AL</searchLink>; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Helppi+MJ%22">Helppi MJ</searchLink>; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Tuladhar+A%22">Tuladhar A</searchLink>; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Penko+AL%22">Penko AL</searchLink>; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Holley+S%22">Holley S</searchLink>; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Nehls+B%22">Nehls B</searchLink>; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Paulino+S%22">Paulino S</searchLink>; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Streicher+MC%22">Streicher MC</searchLink>; Concussion Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Zhu+A%22">Zhu A</searchLink>; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Bruening+K%22">Bruening K</searchLink>; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Durgerian+S%22">Durgerian S</searchLink>; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Koenig+K%22">Koenig K</searchLink>; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Lowe+M%22">Lowe M</searchLink>; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Shin+W%22">Shin W</searchLink>; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Jones+SE%22">Jones SE</searchLink>; Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Galioto+R%22">Galioto R</searchLink>; Mellen Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Pillai+JA%22">Pillai JA</searchLink>; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Bekris+LM%22">Bekris LM</searchLink>; Lerner Research Institute, Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Leverenz+JB%22">Leverenz JB</searchLink>; Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Rosenfeldt+AB%22">Rosenfeldt AB</searchLink>; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Singh+T%22">Singh T</searchLink>; Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Beck+GJ%22">Beck GJ</searchLink>; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.<br /><searchLink fieldCode="AU" term="%22Smith+JC%22">Smith JC</searchLink>; Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD, United States.<br /><searchLink fieldCode="AU" term="%22Alberts+J%22">Alberts J</searchLink>; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.; Concussion Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101525824%22">Frontiers in aging neuroscience</searchLink> [Front Aging Neurosci] 2025 May 27; Vol. 17, pp. 1584115. <i>Date of Electronic Publication: </i>2025 May 27 (<i>Print Publication: </i>2025). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation%22">Frontiers Research Foundation </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101525824 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1663-4365 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216634365%22">16634365 </searchLink><i>NLM ISO Abbreviation: </i>Front Aging Neurosci <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=40496973 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3389/fnagi.2025.1584115 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1584115 Titles: – TitleFull: Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rao SM – PersonEntity: Name: NameFull: Chorba AL – PersonEntity: Name: NameFull: Helppi MJ – PersonEntity: Name: NameFull: Tuladhar A – PersonEntity: Name: NameFull: Penko AL – PersonEntity: Name: NameFull: Holley S – PersonEntity: Name: NameFull: Nehls B – PersonEntity: Name: NameFull: Paulino S – PersonEntity: Name: NameFull: Streicher MC – PersonEntity: Name: NameFull: Zhu A – PersonEntity: Name: NameFull: Bruening K – PersonEntity: Name: NameFull: Durgerian S – PersonEntity: Name: NameFull: Koenig K – PersonEntity: Name: NameFull: Lowe M – PersonEntity: Name: NameFull: Shin W – PersonEntity: Name: NameFull: Jones SE – PersonEntity: Name: NameFull: Galioto R – PersonEntity: Name: NameFull: Pillai JA – PersonEntity: Name: NameFull: Bekris LM – PersonEntity: Name: NameFull: Leverenz JB – PersonEntity: Name: NameFull: Rosenfeldt AB – PersonEntity: Name: NameFull: Singh T – PersonEntity: Name: NameFull: Beck GJ – PersonEntity: Name: NameFull: Smith JC – PersonEntity: Name: NameFull: Alberts J IsPartOfRelationships: – BibEntity: Dates: – D: 27 M: 05 Text: 2025 May 27 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 1663-4365 Numbering: – Type: volume Value: 17 Titles: – TitleFull: Frontiers in aging neuroscience Type: main |
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