Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms.
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| Title: | Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms. |
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| Authors: | Mobach S; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.; Amsterdam University Medical Center location University of Amsterdam, Department of Hematology, Amsterdam 1105 AZ, The Netherlands.; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands., Bergkamp ND; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands., Ma Z; Department of Biomolecular Mass Spectrometry and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht 3584 CH, The Netherlands.; Singapore Immunology Network, Agency for Science, Technology and Research, Immunos, Singapore 138648, Republic of Singapore., Haselager MV; Amsterdam University Medical Center location University of Amsterdam, Department of Hematology, Amsterdam 1105 AZ, The Netherlands.; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands.; Cancer Center Amsterdam, Cancer Immunology, Amsterdam 1081 HV, The Netherlands., Anbuhl SM; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.; QVQ Holding B.V., Utrecht 3584 CL, The Netherlands., Jurriens D; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht 3584 CH, Netherlands., van den Bor J; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands., Wang Z; Receptor Signaling Group, Max Delbrück Center for Molecular Medicine, Berlin 13125, Germany.; ISAR Bioscience Institute, Planegg 82152, Germany., Crudden C; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands., Roos JL; Amsterdam University Medical Center location University of Amsterdam, Department of Hematology, Amsterdam 1105 AZ, The Netherlands.; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands.; Cancer Center Amsterdam, Cancer Immunology, Amsterdam 1081 HV, The Netherlands., Perez Almeria CV; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands., Boergonje RA; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands., Lohse MJ; Receptor Signaling Group, Max Delbrück Center for Molecular Medicine, Berlin 13125, Germany.; ISAR Bioscience Institute, Planegg 82152, Germany., Bosma R; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands., Eldering E; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands.; Cancer Center Amsterdam, Cancer Immunology, Amsterdam 1081 HV, The Netherlands.; Amsterdam University Medical Center location University of Amsterdam, Department of Experimental Immunology, Amsterdam 1105 AZ, The Netherlands.; Amsterdam Institute for Infection and Immunity, Cancer Immunology, Amsterdam 1105 AZ, The Netherlands., Siderius M; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands., Wu W; Department of Biomolecular Mass Spectrometry and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht 3584 CH, The Netherlands.; Singapore Immunology Network, Agency for Science, Technology and Research, Immunos, Singapore 138648, Republic of Singapore.; Department of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore, Singapore 117543, Republic of Singapore., Spaargaren M; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands.; Department of Pathology, Amsterdam University Medical Center location University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.; Cancer Center Amsterdam, Cancer Biology and Immunology-Target & Therapy discovery, Amsterdam 1081 HV, The Netherlands., Tonino SH; Amsterdam University Medical Center location University of Amsterdam, Department of Hematology, Amsterdam 1105 AZ, The Netherlands.; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands., Kater AP; Amsterdam University Medical Center location University of Amsterdam, Department of Hematology, Amsterdam 1105 AZ, The Netherlands.; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands., Smit MJ; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands., Heukers R; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.; QVQ Holding B.V., Utrecht 3584 CL, The Netherlands. |
| Source: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2025 Jun 17; Vol. 122 (24), pp. e2424186122. Date of Electronic Publication: 2025 Jun 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 40498456 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Mobach+S%22">Mobach S</searchLink>; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.; Amsterdam University Medical Center location University of Amsterdam, Department of Hematology, Amsterdam 1105 AZ, The Netherlands.; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bergkamp+ND%22">Bergkamp ND</searchLink>; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Ma+Z%22">Ma Z</searchLink>; Department of Biomolecular Mass Spectrometry and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht 3584 CH, The Netherlands.; Singapore Immunology Network, Agency for Science, Technology and Research, Immunos, Singapore 138648, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Haselager+MV%22">Haselager MV</searchLink>; Amsterdam University Medical Center location University of Amsterdam, Department of Hematology, Amsterdam 1105 AZ, The Netherlands.; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands.; Cancer Center Amsterdam, Cancer Immunology, Amsterdam 1081 HV, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Anbuhl+SM%22">Anbuhl SM</searchLink>; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.; QVQ Holding B.V., Utrecht 3584 CL, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Jurriens+D%22">Jurriens D</searchLink>; Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht 3584 CH, Netherlands.<br /><searchLink fieldCode="AU" term="%22van+den+Bor+J%22">van den Bor J</searchLink>; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Receptor Signaling Group, Max Delbrück Center for Molecular Medicine, Berlin 13125, Germany.; ISAR Bioscience Institute, Planegg 82152, Germany.<br /><searchLink fieldCode="AU" term="%22Crudden+C%22">Crudden C</searchLink>; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Roos+JL%22">Roos JL</searchLink>; Amsterdam University Medical Center location University of Amsterdam, Department of Hematology, Amsterdam 1105 AZ, The Netherlands.; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands.; Cancer Center Amsterdam, Cancer Immunology, Amsterdam 1081 HV, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Perez+Almeria+CV%22">Perez Almeria CV</searchLink>; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Boergonje+RA%22">Boergonje RA</searchLink>; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lohse+MJ%22">Lohse MJ</searchLink>; Receptor Signaling Group, Max Delbrück Center for Molecular Medicine, Berlin 13125, Germany.; ISAR Bioscience Institute, Planegg 82152, Germany.<br /><searchLink fieldCode="AU" term="%22Bosma+R%22">Bosma R</searchLink>; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Eldering+E%22">Eldering E</searchLink>; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands.; Cancer Center Amsterdam, Cancer Immunology, Amsterdam 1081 HV, The Netherlands.; Amsterdam University Medical Center location University of Amsterdam, Department of Experimental Immunology, Amsterdam 1105 AZ, The Netherlands.; Amsterdam Institute for Infection and Immunity, Cancer Immunology, Amsterdam 1105 AZ, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Siderius+M%22">Siderius M</searchLink>; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wu+W%22">Wu W</searchLink>; Department of Biomolecular Mass Spectrometry and Proteomics, Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht 3584 CH, The Netherlands.; Singapore Immunology Network, Agency for Science, Technology and Research, Immunos, Singapore 138648, Republic of Singapore.; Department of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore, Singapore 117543, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Spaargaren+M%22">Spaargaren M</searchLink>; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands.; Department of Pathology, Amsterdam University Medical Center location University of Amsterdam, Amsterdam 1105 AZ, The Netherlands.; Cancer Center Amsterdam, Cancer Biology and Immunology-Target & Therapy discovery, Amsterdam 1081 HV, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Tonino+SH%22">Tonino SH</searchLink>; Amsterdam University Medical Center location University of Amsterdam, Department of Hematology, Amsterdam 1105 AZ, The Netherlands.; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Kater+AP%22">Kater AP</searchLink>; Amsterdam University Medical Center location University of Amsterdam, Department of Hematology, Amsterdam 1105 AZ, The Netherlands.; Lymphoma and Myeloma Center Amsterdam, Amsterdam 1105 AZ, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Smit+MJ%22">Smit MJ</searchLink>; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Heukers+R%22">Heukers R</searchLink>; Department of Chemistry and Pharmaceutical Sciences, Division of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam 1081 HZ, The Netherlands.; QVQ Holding B.V., Utrecht 3584 CL, The Netherlands. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2025 Jun 17; Vol. 122 (24), pp. e2424186122. <i>Date of Electronic Publication: </i>2025 Jun 11. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22National+Academy+of+Sciences%22">National Academy of Sciences </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7505876 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1091-6490 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200278424%22">00278424 </searchLink><i>NLM ISO Abbreviation: </i>Proc Natl Acad Sci U S A <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1073/pnas.2424186122 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e2424186122 Titles: – TitleFull: Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mobach S – PersonEntity: Name: NameFull: Bergkamp ND – PersonEntity: Name: NameFull: Ma Z – PersonEntity: Name: NameFull: Haselager MV – PersonEntity: Name: NameFull: Anbuhl SM – PersonEntity: Name: NameFull: Jurriens D – PersonEntity: Name: NameFull: van den Bor J – PersonEntity: Name: NameFull: Wang Z – PersonEntity: Name: NameFull: Crudden C – PersonEntity: Name: NameFull: Roos JL – PersonEntity: Name: NameFull: Perez Almeria CV – PersonEntity: Name: NameFull: Boergonje RA – PersonEntity: Name: NameFull: Lohse MJ – PersonEntity: Name: NameFull: Bosma R – PersonEntity: Name: NameFull: Eldering E – PersonEntity: Name: NameFull: Siderius M – PersonEntity: Name: NameFull: Wu W – PersonEntity: Name: NameFull: Spaargaren M – PersonEntity: Name: NameFull: Tonino SH – PersonEntity: Name: NameFull: Kater AP – PersonEntity: Name: NameFull: Smit MJ – PersonEntity: Name: NameFull: Heukers R IsPartOfRelationships: – BibEntity: Dates: – D: 17 M: 06 Text: 2025 Jun 17 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1091-6490 Numbering: – Type: volume Value: 122 – Type: issue Value: 24 Titles: – TitleFull: Proceedings of the National Academy of Sciences of the United States of America Type: main |
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