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Gut Microbiota Modulation through Akkermansia spp. Supplementation Increases CAR T-cell Potency.

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Title: Gut Microbiota Modulation through Akkermansia spp. Supplementation Increases CAR T-cell Potency.
Authors: Marcos-Kovandzic L; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Gustave Roussy Cancer Campus (GRCC), Clinicobiome, Villejuif, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France., Avagliano M; Department of Agricultural Sciences, University of Naples Federico II, Naples, Italy., Ben Khelil M; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.; Hematology Department, Institut Gustave Roussy, Villejuif, France., Srikanthan J; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.; Hematology Department, Institut Gustave Roussy, Villejuif, France., Abdallah R; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France., Petrocelli V; IFOM ETS, The AIRC Institute of Molecular Oncology, Milano, Italy., Rengassamy J; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.; Hematology Department, Institut Gustave Roussy, Villejuif, France., Alfaro A; Gustave Roussy, UMS AMMICa, CNRS UAR3655, INSERM US23, Villejuif, France., Bied M; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France., Fidelle M; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Gustave Roussy Cancer Campus (GRCC), Clinicobiome, Villejuif, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France., Ferrere G; EverImmune, Gustave Roussy Cancer Center, Villejuif, France., Daillère R; EverImmune, Gustave Roussy Cancer Center, Villejuif, France., Arbab A; Biopathology Department, Institut Gustave Roussy, Villejuif, France., Amine-Hneineh R; Hematology Department, Institut Gustave Roussy, Villejuif, France., Pages A; Bureau de Biostatistique et d'Epidémiologie, Gustave Roussy et CESP U1018, Oncostat, labellisé Ligue Contre le Cancer, Inserm, Villejuif, France., Dartigues P; Biopathology Department, Institut Gustave Roussy, Villejuif, France., Ly P; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France., Simon S; Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington., Durand S; Metabolomics and Cell Biology Platforms UMS AMMICa/UMR 1138, Institut Gustave Roussy, Villejuif, France.; Equipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, Inserm U1138, Université de Paris, Sorbonne Université, Institut Universitaire de France, Paris, France., Gottschlich A; Department of Medicine III, Ludwig Maximilian University Hospital, Ludwig Maximilian University Munich, Munich, Germany.; Division of Clinical Pharmacology, Ludwig Maximilian University Hospital, Ludwig Maximilian University Munich, Member of the German Center for Lung Research, Munich, Germany.; Bavarian Cancer Research Center, Munich, Germany.; German Cancer Consortium, A Partnership Between Ludwig Maximilian University Hospital and German Cancer Consortium Heidelberg, Munich, Germany., Ginhoux F; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France., Blériot C; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France., Liu P; Metabolomics and Cell Biology Platforms UMS AMMICa/UMR 1138, Institut Gustave Roussy, Villejuif, France.; Equipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, Inserm U1138, Université de Paris, Sorbonne Université, Institut Universitaire de France, Paris, France., Zhao L; Metabolomics and Cell Biology Platforms UMS AMMICa/UMR 1138, Institut Gustave Roussy, Villejuif, France.; Equipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, Inserm U1138, Université de Paris, Sorbonne Université, Institut Universitaire de France, Paris, France., Creusot L; Paris Center for Microbiome Medicine (PaCeMM) FHU, AP-HP, Paris, France.; Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, Sorbonne Universite, INSERM, Paris, France., Rolhion N; Paris Center for Microbiome Medicine (PaCeMM) FHU, AP-HP, Paris, France.; Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, Sorbonne Universite, INSERM, Paris, France., Derosa L; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Gustave Roussy Cancer Campus (GRCC), Clinicobiome, Villejuif, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France., Kroemer G; Equipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, Inserm U1138, Université de Paris, Sorbonne Université, Institut Universitaire de France, Paris, France., Menger L; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France., Kobold S; Department of Medicine III, Ludwig Maximilian University Hospital, Ludwig Maximilian University Munich, Munich, Germany.; Bavarian Cancer Research Center, Munich, Germany.; German Cancer Consortium, A Partnership Between Ludwig Maximilian University Hospital and German Cancer Consortium Heidelberg, Munich, Germany., Castilla-Llorente C; Hematology Department, Institut Gustave Roussy, Villejuif, France., Sokol H; Paris Center for Microbiome Medicine (PaCeMM) FHU, AP-HP, Paris, France.; Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, Sorbonne Universite, INSERM, Paris, France., Casola S; IFOM ETS, The AIRC Institute of Molecular Oncology, Milano, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milano, Milano, Italy., Pasolli E; Department of Agricultural Sciences, University of Naples Federico II, Naples, Italy., Zitvogel L; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Gustave Roussy Cancer Campus (GRCC), Clinicobiome, Villejuif, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France., Bigenwald C; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.; Hematology Department, Institut Gustave Roussy, Villejuif, France.
Source: Cancer discovery [Cancer Discov] 2025 Sep 04; Vol. 15 (9), pp. 1905-1926.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Gut Microbiota Modulation through Akkermansia spp. Supplementation Increases CAR T-cell Potency.
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  Data: <searchLink fieldCode="AU" term="%22Marcos-Kovandzic+L%22">Marcos-Kovandzic L</searchLink>; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Gustave Roussy Cancer Campus (GRCC), Clinicobiome, Villejuif, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Avagliano+M%22">Avagliano M</searchLink>; Department of Agricultural Sciences, University of Naples Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Ben+Khelil+M%22">Ben Khelil M</searchLink>; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.; Hematology Department, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Srikanthan+J%22">Srikanthan J</searchLink>; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.; Hematology Department, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Abdallah+R%22">Abdallah R</searchLink>; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Petrocelli+V%22">Petrocelli V</searchLink>; IFOM ETS, The AIRC Institute of Molecular Oncology, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Rengassamy+J%22">Rengassamy J</searchLink>; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.; Hematology Department, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Alfaro+A%22">Alfaro A</searchLink>; Gustave Roussy, UMS AMMICa, CNRS UAR3655, INSERM US23, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Bied+M%22">Bied M</searchLink>; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Fidelle+M%22">Fidelle M</searchLink>; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Gustave Roussy Cancer Campus (GRCC), Clinicobiome, Villejuif, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Ferrere+G%22">Ferrere G</searchLink>; EverImmune, Gustave Roussy Cancer Center, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Daillère+R%22">Daillère R</searchLink>; EverImmune, Gustave Roussy Cancer Center, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Arbab+A%22">Arbab A</searchLink>; Biopathology Department, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Amine-Hneineh+R%22">Amine-Hneineh R</searchLink>; Hematology Department, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Pages+A%22">Pages A</searchLink>; Bureau de Biostatistique et d'Epidémiologie, Gustave Roussy et CESP U1018, Oncostat, labellisé Ligue Contre le Cancer, Inserm, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Dartigues+P%22">Dartigues P</searchLink>; Biopathology Department, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Ly+P%22">Ly P</searchLink>; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Simon+S%22">Simon S</searchLink>; Translational Sciences and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Durand+S%22">Durand S</searchLink>; Metabolomics and Cell Biology Platforms UMS AMMICa/UMR 1138, Institut Gustave Roussy, Villejuif, France.; Equipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, Inserm U1138, Université de Paris, Sorbonne Université, Institut Universitaire de France, Paris, France.<br /><searchLink fieldCode="AU" term="%22Gottschlich+A%22">Gottschlich A</searchLink>; Department of Medicine III, Ludwig Maximilian University Hospital, Ludwig Maximilian University Munich, Munich, Germany.; Division of Clinical Pharmacology, Ludwig Maximilian University Hospital, Ludwig Maximilian University Munich, Member of the German Center for Lung Research, Munich, Germany.; Bavarian Cancer Research Center, Munich, Germany.; German Cancer Consortium, A Partnership Between Ludwig Maximilian University Hospital and German Cancer Consortium Heidelberg, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Ginhoux+F%22">Ginhoux F</searchLink>; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Blériot+C%22">Blériot C</searchLink>; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Liu+P%22">Liu P</searchLink>; Metabolomics and Cell Biology Platforms UMS AMMICa/UMR 1138, Institut Gustave Roussy, Villejuif, France.; Equipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, Inserm U1138, Université de Paris, Sorbonne Université, Institut Universitaire de France, Paris, France.<br /><searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; Metabolomics and Cell Biology Platforms UMS AMMICa/UMR 1138, Institut Gustave Roussy, Villejuif, France.; Equipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, Inserm U1138, Université de Paris, Sorbonne Université, Institut Universitaire de France, Paris, France.<br /><searchLink fieldCode="AU" term="%22Creusot+L%22">Creusot L</searchLink>; Paris Center for Microbiome Medicine (PaCeMM) FHU, AP-HP, Paris, France.; Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, Sorbonne Universite, INSERM, Paris, France.<br /><searchLink fieldCode="AU" term="%22Rolhion+N%22">Rolhion N</searchLink>; Paris Center for Microbiome Medicine (PaCeMM) FHU, AP-HP, Paris, France.; Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, Sorbonne Universite, INSERM, Paris, France.<br /><searchLink fieldCode="AU" term="%22Derosa+L%22">Derosa L</searchLink>; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Gustave Roussy Cancer Campus (GRCC), Clinicobiome, Villejuif, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Kroemer+G%22">Kroemer G</searchLink>; Equipe labellisée par la Ligue contre le cancer, Centre de Recherche des Cordeliers, Inserm U1138, Université de Paris, Sorbonne Université, Institut Universitaire de France, Paris, France.<br /><searchLink fieldCode="AU" term="%22Menger+L%22">Menger L</searchLink>; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Kobold+S%22">Kobold S</searchLink>; Department of Medicine III, Ludwig Maximilian University Hospital, Ludwig Maximilian University Munich, Munich, Germany.; Bavarian Cancer Research Center, Munich, Germany.; German Cancer Consortium, A Partnership Between Ludwig Maximilian University Hospital and German Cancer Consortium Heidelberg, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Castilla-Llorente+C%22">Castilla-Llorente C</searchLink>; Hematology Department, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Sokol+H%22">Sokol H</searchLink>; Paris Center for Microbiome Medicine (PaCeMM) FHU, AP-HP, Paris, France.; Centre de Recherche Saint-Antoine, CRSA, AP-HP, Saint Antoine Hospital, Gastroenterology Department, Sorbonne Universite, INSERM, Paris, France.<br /><searchLink fieldCode="AU" term="%22Casola+S%22">Casola S</searchLink>; IFOM ETS, The AIRC Institute of Molecular Oncology, Milano, Italy.; Department of Medical Biotechnology and Translational Medicine, University of Milano, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Pasolli+E%22">Pasolli E</searchLink>; Department of Agricultural Sciences, University of Naples Federico II, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Zitvogel+L%22">Zitvogel L</searchLink>; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Gustave Roussy Cancer Campus (GRCC), Clinicobiome, Villejuif, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Bigenwald+C%22">Bigenwald C</searchLink>; Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France.; Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Institut Gustave Roussy, Villejuif, France.; Hematology Department, Institut Gustave Roussy, Villejuif, France.
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