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Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation.

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Title: Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation.
Authors: Wang ZC; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Li C; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Zhang Z; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Lu S; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Liu YM; Department of Pathology, First Hospital of Jilin University, Changchun, 130021, China., Qi P; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Chen X; Department of Neurosurgery, Second Hospital of Jilin University, Changchun, 130021, China., Wang YB; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Feng WJ; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Pan CL; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Wang QX; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Ji ZL; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Yu Y; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Piao MH; Department of Anesthesiology, First Hospital of Jilin University, Changchun, 130021, China., Chi GF; Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China., Ge PF; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China. gepf@jlu.edu.cn.; Tumor Research Institute of Jilin University, First Hospital of Jilin University, Changchun, 130021, China. gepf@jlu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Nov; Vol. 46 (11), pp. 3071-3086. Date of Electronic Publication: 2025 Jun 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation.
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  Data: <searchLink fieldCode="AU" term="%22Wang+ZC%22">Wang ZC</searchLink>; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Lu+S%22">Lu S</searchLink>; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Liu+YM%22">Liu YM</searchLink>; Department of Pathology, First Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Qi+P%22">Qi P</searchLink>; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Neurosurgery, Second Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Wang+YB%22">Wang YB</searchLink>; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Feng+WJ%22">Feng WJ</searchLink>; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Pan+CL%22">Pan CL</searchLink>; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Wang+QX%22">Wang QX</searchLink>; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Ji+ZL%22">Ji ZL</searchLink>; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Piao+MH%22">Piao MH</searchLink>; Department of Anesthesiology, First Hospital of Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Chi+GF%22">Chi GF</searchLink>; Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China.<br /><searchLink fieldCode="AU" term="%22Ge+PF%22">Ge PF</searchLink>; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China. gepf@jlu.edu.cn.; Tumor Research Institute of Jilin University, First Hospital of Jilin University, Changchun, 130021, China. gepf@jlu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2025 Nov; Vol. 46 (11), pp. 3071-3086. <i>Date of Electronic Publication: </i>2025 Jun 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100956087 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-7254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216714083%22">16714083 </searchLink><i>NLM ISO Abbreviation: </i>Acta Pharmacol Sin <i>Subsets: </i>MEDLINE
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