Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation.
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| Title: | Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation. |
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| Authors: | Wang ZC; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Li C; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Zhang Z; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Lu S; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Liu YM; Department of Pathology, First Hospital of Jilin University, Changchun, 130021, China., Qi P; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Chen X; Department of Neurosurgery, Second Hospital of Jilin University, Changchun, 130021, China., Wang YB; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Feng WJ; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Pan CL; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Wang QX; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Ji ZL; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Yu Y; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China., Piao MH; Department of Anesthesiology, First Hospital of Jilin University, Changchun, 130021, China., Chi GF; Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, 130021, China., Ge PF; Department of Neurosurgery, First Hospital of Jilin University, Changchun, 130021, China. gepf@jlu.edu.cn.; Tumor Research Institute of Jilin University, First Hospital of Jilin University, Changchun, 130021, China. gepf@jlu.edu.cn. |
| Source: | Acta pharmacologica Sinica [Acta Pharmacol Sin] 2025 Nov; Vol. 46 (11), pp. 3071-3086. Date of Electronic Publication: 2025 Jun 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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