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Early life high fructose impairs microglial phagocytosis and neurodevelopment.

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Title: Early life high fructose impairs microglial phagocytosis and neurodevelopment.
Authors: Wang Z; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY, USA., Lipshutz A; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Martínez de la Torre C; Department of Radiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Trzeciak AJ; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Liu ZL; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Miranda IC; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA., Lazarov T; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Codo AC; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY, USA., Romero-Pichardo JE; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Nair A; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Schild T; Department of Radiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Saitz Rojas W; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Saavedra PHV; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Biology, Northeastern University, Boston, MA, USA., Baako AK; Neuroscience Graduate Program, Weill Cornell Medicine, New York, NY, USA., Fadojutimi K; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Downey MS; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY, USA., Geissmann F; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY, USA., Faraco G; Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA., Gan L; Helen and Robert Appel Alzheimer's Disease Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA., Etchegaray JI; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Lucas CD; University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.; Institute for Regeneration and Repair, Edinburgh, UK., Tanasova M; Department of Chemistry, Michigan Technological University, Houghton, MI, USA.; Health Research Institute, Michigan Technological University, Houghton, MI, USA., Parkhurst CN; Department of Radiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zeng MY; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY, USA.; Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, USA.; Department of Pediatrics, Neonatal Medicine, Weill Cornell Medicine, New York, NY, USA., Keshari KR; Department of Radiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Perry JSA; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. perryj@mskcc.org.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY, USA. perryj@mskcc.org.; Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. perryj@mskcc.org.
Source: Nature [Nature] 2025 Aug; Vol. 644 (8077), pp. 759-768. Date of Electronic Publication: 2025 Jun 11.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Early life high fructose impairs microglial phagocytosis and neurodevelopment.
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  Data: <searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lipshutz+A%22">Lipshutz A</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Martínez+de+la+Torre+C%22">Martínez de la Torre C</searchLink>; Department of Radiology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Molecular Pharmacology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Trzeciak+AJ%22">Trzeciak AJ</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Liu+ZL%22">Liu ZL</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Miranda+IC%22">Miranda IC</searchLink>; Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lazarov+T%22">Lazarov T</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Codo+AC%22">Codo AC</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Romero-Pichardo+JE%22">Romero-Pichardo JE</searchLink>; Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Louis V. 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Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. perryj@mskcc.org.
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