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Procyanidins as potential anticancer agents: mechanisms of action, bioavailability challenges and therapeutic opportunities.

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Title: Procyanidins as potential anticancer agents: mechanisms of action, bioavailability challenges and therapeutic opportunities.
Authors: Ademiluyi AO; Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, Akure, 340252, Nigeria., Oyeniran OH; Department of Biochemistry, Federal University, Oye-Ekiti, Nigeria., Del Prado-Audelo ML; Tecnologico de Monterrey, Campus Ciudad de México, 14380, Mexico City, Mexico., Romero-Montero A; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Mexico City, Mexico., Leyva-Gómez G; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Mexico City, Mexico. leyva@quimica.unam.mx., Dini I; Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131, Naples, Italy. irdini@unina.it., Habtemariam S; Pharmacognosy Research & Herbal Analysis Services UK, Central Avenue, Chatham-Maritime, KEN, ME4 4TB, UK., Setzer WN; Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT, 84043, USA.; Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, 35899, USA., Sharifi-Rad J; Universidad Espíritu Santo, Samborondón, 092301, Ecuador. javad.sharifirad@gmail.com.; Centro de Estudios Tecnológicosy , Universitarios del Golfo, Veracruz, Mexico. javad.sharifirad@gmail.com.; Department of Medicine, College of Medicine, Korea University, Seoul, 02841, Republic of Korea. javad.sharifirad@gmail.com., Calina D; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania. calinadaniela@gmail.com.
Source: Medical oncology (Northwood, London, England) [Med Oncol] 2025 Jun 11; Vol. 42 (7), pp. 251. Date of Electronic Publication: 2025 Jun 11.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Procyanidins as potential anticancer agents: mechanisms of action, bioavailability challenges and therapeutic opportunities.
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  Data: <searchLink fieldCode="AU" term="%22Ademiluyi+AO%22">Ademiluyi AO</searchLink>; Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, Akure, 340252, Nigeria.<br /><searchLink fieldCode="AU" term="%22Oyeniran+OH%22">Oyeniran OH</searchLink>; Department of Biochemistry, Federal University, Oye-Ekiti, Nigeria.<br /><searchLink fieldCode="AU" term="%22Del+Prado-Audelo+ML%22">Del Prado-Audelo ML</searchLink>; Tecnologico de Monterrey, Campus Ciudad de México, 14380, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Romero-Montero+A%22">Romero-Montero A</searchLink>; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Mexico City, Mexico.<br /><searchLink fieldCode="AU" term="%22Leyva-Gómez+G%22">Leyva-Gómez G</searchLink>; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, 04510, Mexico City, Mexico. leyva@quimica.unam.mx.<br /><searchLink fieldCode="AU" term="%22Dini+I%22">Dini I</searchLink>; Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131, Naples, Italy. irdini@unina.it.<br /><searchLink fieldCode="AU" term="%22Habtemariam+S%22">Habtemariam S</searchLink>; Pharmacognosy Research & Herbal Analysis Services UK, Central Avenue, Chatham-Maritime, KEN, ME4 4TB, UK.<br /><searchLink fieldCode="AU" term="%22Setzer+WN%22">Setzer WN</searchLink>; Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT, 84043, USA.; Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, 35899, USA.<br /><searchLink fieldCode="AU" term="%22Sharifi-Rad+J%22">Sharifi-Rad J</searchLink>; Universidad Espíritu Santo, Samborondón, 092301, Ecuador. javad.sharifirad@gmail.com.; Centro de Estudios Tecnológicosy , Universitarios del Golfo, Veracruz, Mexico. javad.sharifirad@gmail.com.; Department of Medicine, College of Medicine, Korea University, Seoul, 02841, Republic of Korea. javad.sharifirad@gmail.com.<br /><searchLink fieldCode="AU" term="%22Calina+D%22">Calina D</searchLink>; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania. calinadaniela@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%229435512%22">Medical oncology (Northwood, London, England)</searchLink> [Med Oncol] 2025 Jun 11; Vol. 42 (7), pp. 251. <i>Date of Electronic Publication: </i>2025 Jun 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9435512 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1559-131X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213570560%22">13570560 </searchLink><i>NLM ISO Abbreviation: </i>Med Oncol <i>Subsets: </i>MEDLINE
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              Text: 2025 Jun 11
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