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Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Defects through Dysregulation of DNA Methylation.

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Title: Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Defects through Dysregulation of DNA Methylation.
Authors: van der Veer BK; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium., Custers C; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium., Brangers W; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium., Cornelis R; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium., Tsaniras SC; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium., Ridder K; Laboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium., Thienpont B; Laboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium., Cheng H; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA., Chen Q; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA., Kraushaar D; Department of Molecular and Cellular Biology, Genomic and RNA Profiling Core, Baylor College of Medicine, Houston, Texas, USA., Finnell RH; Department of Molecular and Cellular Biology, Center for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, USA.; Department of Molecular and Human Genetics, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA., Gross SS; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA., Koh KP; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.; Department of Molecular and Cellular Biology, Center for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 May 30. Date of Electronic Publication: 2025 May 30.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Maternal Vitamin C Deficiency and Genetic Risk Factors Contribute to Congenital Defects through Dysregulation of DNA Methylation.
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  Data: <searchLink fieldCode="AU" term="%22van+der+Veer+BK%22">van der Veer BK</searchLink>; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Custers+C%22">Custers C</searchLink>; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Brangers+W%22">Brangers W</searchLink>; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Cornelis+R%22">Cornelis R</searchLink>; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Tsaniras+SC%22">Tsaniras SC</searchLink>; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Ridder+K%22">Ridder K</searchLink>; Laboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Thienpont+B%22">Thienpont B</searchLink>; Laboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven 3000, Belgium.<br /><searchLink fieldCode="AU" term="%22Cheng+H%22">Cheng H</searchLink>; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Kraushaar+D%22">Kraushaar D</searchLink>; Department of Molecular and Cellular Biology, Genomic and RNA Profiling Core, Baylor College of Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Finnell+RH%22">Finnell RH</searchLink>; Department of Molecular and Cellular Biology, Center for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, USA.; Department of Molecular and Human Genetics, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Gross+SS%22">Gross SS</searchLink>; Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA.<br /><searchLink fieldCode="AU" term="%22Koh+KP%22">Koh KP</searchLink>; Laboratory for Stem Cell and Developmental Epigenetics, Department of Development and Regeneration, KU Leuven, Leuven 3000, Belgium.; Department of Molecular and Cellular Biology, Center for Precision Environmental Health, Baylor College of Medicine, Houston, Texas, USA.
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