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trans-Cyclooctene-caged-IL-1β immunocytokine-constructs ligated to unmodified nanobodies allow click-2-release-based control of cytokine activity.

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Title: trans-Cyclooctene-caged-IL-1β immunocytokine-constructs ligated to unmodified nanobodies allow click-2-release-based control of cytokine activity.
Authors: Barendrecht A; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl., Peeters HHC; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl., Torres-García D; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl., Shema MT; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl., Sarris AJC; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl., David S; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl., Aba G; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl.; Leiden University Medical Center Albinusdreef 2 Leiden The Netherlands., Le Gall CM; Department of Medical BioSciences, Radboud University Medical Center Nijmegen The Netherlands., Wilkovitsch M; Institute of Applied Synthetic Chemistry, TU Wien Getreidemarkt 9/163 Vienna Austria., Verdoes M; Department of Medical BioSciences, Radboud University Medical Center Nijmegen The Netherlands.; Institute for Chemical Immunology Nijmegen The Netherlands.; Current address: Department of Immunology, Leiden University Medical Center Leiden The Netherlands., Mikula H; Institute of Applied Synthetic Chemistry, TU Wien Getreidemarkt 9/163 Vienna Austria., Travis MA; Manchester Collaborative Centre for Inflammation Research, University of Manchester Manchester UK., van Kasteren SI; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl.
Source: RSC chemical biology [RSC Chem Biol] 2025 Jun 04; Vol. 6 (7), pp. 1068-1078. Date of Electronic Publication: 2025 Jun 04 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101768727 Publication Model: eCollection Cited Medium: Internet ISSN: 2633-0679 (Electronic) Linking ISSN: 26330679 NLM ISO Abbreviation: RSC Chem Biol Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Barendrecht+A%22">Barendrecht A</searchLink>; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl.<br /><searchLink fieldCode="AU" term="%22Peeters+HHC%22">Peeters HHC</searchLink>; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl.<br /><searchLink fieldCode="AU" term="%22Torres-García+D%22">Torres-García D</searchLink>; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl.<br /><searchLink fieldCode="AU" term="%22Shema+MT%22">Shema MT</searchLink>; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl.<br /><searchLink fieldCode="AU" term="%22Sarris+AJC%22">Sarris AJC</searchLink>; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl.<br /><searchLink fieldCode="AU" term="%22David+S%22">David S</searchLink>; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl.<br /><searchLink fieldCode="AU" term="%22Aba+G%22">Aba G</searchLink>; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl.; Leiden University Medical Center Albinusdreef 2 Leiden The Netherlands.<br /><searchLink fieldCode="AU" term="%22Le+Gall+CM%22">Le Gall CM</searchLink>; Department of Medical BioSciences, Radboud University Medical Center Nijmegen The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wilkovitsch+M%22">Wilkovitsch M</searchLink>; Institute of Applied Synthetic Chemistry, TU Wien Getreidemarkt 9/163 Vienna Austria.<br /><searchLink fieldCode="AU" term="%22Verdoes+M%22">Verdoes M</searchLink>; Department of Medical BioSciences, Radboud University Medical Center Nijmegen The Netherlands.; Institute for Chemical Immunology Nijmegen The Netherlands.; Current address: Department of Immunology, Leiden University Medical Center Leiden The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mikula+H%22">Mikula H</searchLink>; Institute of Applied Synthetic Chemistry, TU Wien Getreidemarkt 9/163 Vienna Austria.<br /><searchLink fieldCode="AU" term="%22Travis+MA%22">Travis MA</searchLink>; Manchester Collaborative Centre for Inflammation Research, University of Manchester Manchester UK.<br /><searchLink fieldCode="AU" term="%22van+Kasteren+SI%22">van Kasteren SI</searchLink>; Division of Chemical Biology and Immunology, Leiden Institute of Chemistry, Universiteit Leiden Gorlaeus Laboratory, Einsteinweg 55 Leiden The Netherlands s.i.van.kasteren@chem.leidenuniv.nl.
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  Data: <searchLink fieldCode="JN" term="%22101768727%22">RSC chemical biology</searchLink> [RSC Chem Biol] 2025 Jun 04; Vol. 6 (7), pp. 1068-1078. <i>Date of Electronic Publication: </i>2025 Jun 04 (<i>Print Publication: </i>2025).
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