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Pharmacological inhibitors of the gamma-secretase enzyme complex disrupt epithelial cell function triggering colitis in mice.

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Title: Pharmacological inhibitors of the gamma-secretase enzyme complex disrupt epithelial cell function triggering colitis in mice.
Authors: Erkert L; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Kabisch M; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Gamez-Belmonte R; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Gonzalez-Acera M; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Patankar JV; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany., Schödel L; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Hofmann K; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Wagner Y; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Plattner C; Institute for Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria., Spath EM; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Distler U; Institute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz, Germany., Tenzer S; Institute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz, Germany., Neufert C; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany., Neurath MF; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany., Becker C; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.
Corporate Authors: TRR241 IBDome Consortium
Source: Journal of Crohn's & colitis [J Crohns Colitis] 2025 Jul 03; Vol. 19 (7).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 101318676 Publication Model: Print Cited Medium: Internet ISSN: 1876-4479 (Electronic) Linking ISSN: 18739946 NLM ISO Abbreviation: J Crohns Colitis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacological inhibitors of the gamma-secretase enzyme complex disrupt epithelial cell function triggering colitis in mice.
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  Data: <searchLink fieldCode="AU" term="%22Erkert+L%22">Erkert L</searchLink>; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Kabisch+M%22">Kabisch M</searchLink>; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Gamez-Belmonte+R%22">Gamez-Belmonte R</searchLink>; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Gonzalez-Acera+M%22">Gonzalez-Acera M</searchLink>; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Patankar+JV%22">Patankar JV</searchLink>; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Schödel+L%22">Schödel L</searchLink>; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Hofmann+K%22">Hofmann K</searchLink>; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+Y%22">Wagner Y</searchLink>; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Plattner+C%22">Plattner C</searchLink>; Institute for Bioinformatics, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Spath+EM%22">Spath EM</searchLink>; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Distler+U%22">Distler U</searchLink>; Institute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Tenzer+S%22">Tenzer S</searchLink>; Institute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Neufert+C%22">Neufert C</searchLink>; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Neurath+MF%22">Neurath MF</searchLink>; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Becker+C%22">Becker C</searchLink>; Department of Medicine 1, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101318676 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1876-4479 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218739946%22">18739946 </searchLink><i>NLM ISO Abbreviation: </i>J Crohns Colitis <i>Subsets: </i>MEDLINE
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        Value: 10.1093/ecco-jcc/jjaf096
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              Text: 2025 Jul 03
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