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Disease severity across psychiatric disorders is linked to pro-inflammatory cytokines.

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Title: Disease severity across psychiatric disorders is linked to pro-inflammatory cytokines.
Authors: Solomon P; Nantes Université, CHU-Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France., Budde M; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany., Kohshour MO; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran., Adorjan K; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland., Heilbronner M; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany., Navarro-Flores A; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany., Papiol S; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; Max Planck Institute of Psychiatry, Munich, Germany., Reich-Erkelenz D; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany., Schulte EC; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich 80336, Germany; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Bonn, University of Bonn, Bonn 53127, Germany; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany; German Center for Mental Health (DZPG), Partner Site Munich/Augsburg, Munich, Germany., Senner F; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich 80336, Germany; Centres for Psychiatry Suedwuerttemberg, Ravensburg 88214, Germany., Vogl T; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany., Kaurani L; German Center for Neurodegenerative Diseases (DZNE), Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Göttingen 37075, Germany., Krüger DM; German Center for Neurodegenerative Diseases (DZNE), Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Göttingen 37075, Germany., Sananbenesi F; Research Group for Genome Dynamics in Brain Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Pena T; German Center for Neurodegenerative Diseases (DZNE), Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Göttingen 37075, Germany., Burkhardt S; German Center for Neurodegenerative Diseases (DZNE), Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Göttingen 37075, Germany., Schütz AL; Research Group for Genome Dynamics in Brain Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany., Anghelescu IG; Department of Psychiatry and Psychotherapy, Mental Health Institute Berlin, Berlin 14050, Germany., Arolt V; Institute for Translational Psychiatry, University of Münster, Münster 48149, Germany., Baune BT; Department of Psychiatry, University of Münster, Münster 48149, Germany; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Australia; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster 48149, Germany., Dietrich DE; AMEOS Clinical Center Hildesheim, Hildesheim 31135, Germany; Center for Systems Neuroscience (ZSN), Hannover 30559, Germany; Department of Psychiatry, Medical School of Hannover, Hannover 30625, Germany., Fallgatter AJ; Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health (TüCMH), University of Tübingen, Tübingen 72076, Germany; German Center for Mental Health (DZPG), Partner Site Tübingen, Tübingen 72076, Germany., Figge C; Karl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Oldenburg 26160, Germany., Juckel G; Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum 44791, Germany., Konrad C; Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg 27356, Germany., Lang FU; Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg 89312, Germany., Reimer J; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany; Center for Psychosocial Medicine, Academic Teaching Hospital Itzehoe, Itzehoe, Germany., Reininghaus EZ; Division of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz 8036, Austria., Schmauß M; Clinic for Psychiatry, Psychotherapy and Psychosomatics, Augsburg University, Medical Faculty, Bezirkskrankenhaus Augsburg, Augsburg 86156, Germany., Spitzer C; Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock 18147, Germany., Wiltfang J; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen 37075, Germany; German Center for Neurodegenerative Diseases (DZNE), Göttingen 37075, Germany; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal., Zimmermann J; Psychiatrieverbund Oldenburger Land gGmbH, Karl-Jaspers-Klinik, Bad Zwischenahn 26160, Germany., Fischer A; German Center for Neurodegenerative Diseases (DZNE), Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Göttingen 37075, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen 37075, Germany; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Germany., Falkai P; Max Planck Institute of Psychiatry, Munich, Germany; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich 80336, Germany; German Center for Mental Health (DZPG), Partner Site Munich/Augsburg, Munich, Germany., Schulze TG; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; German Center for Mental Health (DZPG), Partner Site Munich/Augsburg, Munich, Germany; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Heilbronner U; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany. Electronic address: urs.heilbronner@med.uni-muenchen.de., Poschmann J; Nantes Université, CHU-Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France. Electronic address: jeremie.poschmann@univ-nantes.fr.
Source: Brain, behavior, and immunity [Brain Behav Immun] 2025 Oct; Vol. 129, pp. 359-372. Date of Electronic Publication: 2025 Jun 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8800478 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2139 (Electronic) Linking ISSN: 08891591 NLM ISO Abbreviation: Brain Behav Immun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Disease severity across psychiatric disorders is linked to pro-inflammatory cytokines.
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  Data: <searchLink fieldCode="AU" term="%22Solomon+P%22">Solomon P</searchLink>; Nantes Université, CHU-Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.<br /><searchLink fieldCode="AU" term="%22Budde+M%22">Budde M</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany.<br /><searchLink fieldCode="AU" term="%22Kohshour+MO%22">Kohshour MO</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.<br /><searchLink fieldCode="AU" term="%22Adorjan+K%22">Adorjan K</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Heilbronner+M%22">Heilbronner M</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany.<br /><searchLink fieldCode="AU" term="%22Navarro-Flores+A%22">Navarro-Flores A</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Papiol+S%22">Papiol S</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; Max Planck Institute of Psychiatry, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Reich-Erkelenz+D%22">Reich-Erkelenz D</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany.<br /><searchLink fieldCode="AU" term="%22Schulte+EC%22">Schulte EC</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich 80336, Germany; Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Bonn, University of Bonn, Bonn 53127, Germany; Institute of Human Genetics, University Hospital, Faculty of Medicine, University of Bonn, Bonn, Germany; German Center for Mental Health (DZPG), Partner Site Munich/Augsburg, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Senner+F%22">Senner F</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich 80336, Germany; Centres for Psychiatry Suedwuerttemberg, Ravensburg 88214, Germany.<br /><searchLink fieldCode="AU" term="%22Vogl+T%22">Vogl T</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany.<br /><searchLink fieldCode="AU" term="%22Kaurani+L%22">Kaurani L</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Göttingen 37075, Germany.<br /><searchLink fieldCode="AU" term="%22Krüger+DM%22">Krüger DM</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Göttingen 37075, Germany.<br /><searchLink fieldCode="AU" term="%22Sananbenesi+F%22">Sananbenesi F</searchLink>; Research Group for Genome Dynamics in Brain Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Pena+T%22">Pena T</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Göttingen 37075, Germany.<br /><searchLink fieldCode="AU" term="%22Burkhardt+S%22">Burkhardt S</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Göttingen 37075, Germany.<br /><searchLink fieldCode="AU" term="%22Schütz+AL%22">Schütz AL</searchLink>; Research Group for Genome Dynamics in Brain Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Anghelescu+IG%22">Anghelescu IG</searchLink>; Department of Psychiatry and Psychotherapy, Mental Health Institute Berlin, Berlin 14050, Germany.<br /><searchLink fieldCode="AU" term="%22Arolt+V%22">Arolt V</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster 48149, Germany.<br /><searchLink fieldCode="AU" term="%22Baune+BT%22">Baune BT</searchLink>; Department of Psychiatry, University of Münster, Münster 48149, Germany; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, Australia; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Dannlowski+U%22">Dannlowski U</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster 48149, Germany.<br /><searchLink fieldCode="AU" term="%22Dietrich+DE%22">Dietrich DE</searchLink>; AMEOS Clinical Center Hildesheim, Hildesheim 31135, Germany; Center for Systems Neuroscience (ZSN), Hannover 30559, Germany; Department of Psychiatry, Medical School of Hannover, Hannover 30625, Germany.<br /><searchLink fieldCode="AU" term="%22Fallgatter+AJ%22">Fallgatter AJ</searchLink>; Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health (TüCMH), University of Tübingen, Tübingen 72076, Germany; German Center for Mental Health (DZPG), Partner Site Tübingen, Tübingen 72076, Germany.<br /><searchLink fieldCode="AU" term="%22Figge+C%22">Figge C</searchLink>; Karl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Oldenburg 26160, Germany.<br /><searchLink fieldCode="AU" term="%22Juckel+G%22">Juckel G</searchLink>; Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum 44791, Germany.<br /><searchLink fieldCode="AU" term="%22Konrad+C%22">Konrad C</searchLink>; Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg 27356, Germany.<br /><searchLink fieldCode="AU" term="%22Lang+FU%22">Lang FU</searchLink>; Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg 89312, Germany.<br /><searchLink fieldCode="AU" term="%22Reimer+J%22">Reimer J</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany; Center for Psychosocial Medicine, Academic Teaching Hospital Itzehoe, Itzehoe, Germany.<br /><searchLink fieldCode="AU" term="%22Reininghaus+EZ%22">Reininghaus EZ</searchLink>; Division of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz 8036, Austria.<br /><searchLink fieldCode="AU" term="%22Schmauß+M%22">Schmauß M</searchLink>; Clinic for Psychiatry, Psychotherapy and Psychosomatics, Augsburg University, Medical Faculty, Bezirkskrankenhaus Augsburg, Augsburg 86156, Germany.<br /><searchLink fieldCode="AU" term="%22Spitzer+C%22">Spitzer C</searchLink>; Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock 18147, Germany.<br /><searchLink fieldCode="AU" term="%22Wiltfang+J%22">Wiltfang J</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen 37075, Germany; German Center for Neurodegenerative Diseases (DZNE), Göttingen 37075, Germany; Neurosciences and Signaling Group, Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.<br /><searchLink fieldCode="AU" term="%22Zimmermann+J%22">Zimmermann J</searchLink>; Psychiatrieverbund Oldenburger Land gGmbH, Karl-Jaspers-Klinik, Bad Zwischenahn 26160, Germany.<br /><searchLink fieldCode="AU" term="%22Fischer+A%22">Fischer A</searchLink>; German Center for Neurodegenerative Diseases (DZNE), Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, Göttingen 37075, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen 37075, Germany; Cluster of Excellence 'Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells' (MBExC), University of Göttingen, Germany.<br /><searchLink fieldCode="AU" term="%22Falkai+P%22">Falkai P</searchLink>; Max Planck Institute of Psychiatry, Munich, Germany; Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich 80336, Germany; German Center for Mental Health (DZPG), Partner Site Munich/Augsburg, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schulze+TG%22">Schulze TG</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany; German Center for Mental Health (DZPG), Partner Site Munich/Augsburg, Munich, Germany; Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Heilbronner+U%22">Heilbronner U</searchLink>; Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich 80336, Germany. Electronic address: urs.heilbronner@med.uni-muenchen.de.<br /><searchLink fieldCode="AU" term="%22Poschmann+J%22">Poschmann J</searchLink>; Nantes Université, CHU-Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France. Electronic address: jeremie.poschmann@univ-nantes.fr.
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